Chronic Vomiting and Weight Loss: A Case Study of SMA Syndrome - Surgery

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Chronic vomiting (including the expulsion of water)?


Hello Doctor: I have been experiencing headaches since 2011, and starting in April 2012, I began to vomit whenever I ate.
Initially, the vomit was white foam, but it progressively worsened to the point where I would vomit almost all the food I ingested (projectile vomiting starting five minutes after eating, without nausea, lasting two to three hours, eventually vomiting bile and gastric acid).
I have undergone numerous tests but have not found a definitive cause.
I have lost 25 kilograms due to vomiting, and I even vomit water.
I often experience hypokalemia due to frequent vomiting.
Currently, I have a PICC line and am receiving home intravenous nutrition.
I have consulted many hospitals and medical centers and tried various medications.
Diagnoses I have received include cyclic vomiting syndrome, superior mesenteric artery syndrome, rumination syndrome, gastroparesis, and pseudo-chronic intestinal obstruction.
In November 2013, after another CT scan at a medical center, the doctor suspected I had the rare SMA Syndrome, and it was confirmed that my blood vessels were compressing my intestines, with an angle of only 23 degrees (normal range 38°-56°), which prevents food from passing and causes reflux.
I initially thought surgery would resolve the issue, so I underwent duodenojejunostomy and pyloroplasty.
I did not vomit for about a week post-surgery, but then the vomiting returned after a week! I have continued to try various medications, consulted traditional Chinese medicine, received acupuncture, and visited a psychosomatic specialist.
I have taken medication for a while and undergone biofeedback therapy, but there has been no improvement.
I now feel very weak, experience dizziness throughout the day, and can only have bowel movements through enemas, as I vomit after eating.
This has been ongoing for over four years! I am unable to attend school and have withdrawn.
I am truly at a loss for what to do, as I have been repeatedly hospitalized and have undergone numerous gastrointestinal examinations (gastroscopy, abdominal CT, abdominal ultrasound, gastrointestinal imaging, capsule endoscopy, gastric motility studies, esophageal function tests, etc.) and brain examinations (brain CT, MRI, SPECT, EEG, lumbar puncture, etc.), yet the cause of my vomiting remains undetermined (no gag reflex).
Some doctors have suggested further surgery (fundoplication and vagotomy), but it is uncertain whether this would alleviate my symptoms, and it may lead to other complications, so I am still considering my options.
Could you please provide some advice, as I truly do not know what to do? Thank you, Doctor.

Niming, 20~29 year old female. Ask Date: 2016/03/05

Dr. Xu Kaixi reply Surgery


Based on your description, you have undergone numerous tests, yet the exact cause of your vomiting remains unidentified.
It was previously confirmed that you have Superior Mesenteric Artery (SMA) syndrome, for which you underwent surgical treatment.
You experienced improvement for one week post-surgery, but then the symptoms recurred.
Subsequent examinations have not revealed any further causes, and conservative medical treatment has also been ineffective.
If a physician has evaluated you and recommended surgical intervention, you may indeed consider proceeding with the surgery.
Otherwise, you might need to seek evaluation at another medical center to identify potential causes.

Reply Date: 2016/03/05

More Info


Chronic vomiting and significant weight loss can be distressing symptoms that often lead to a complex diagnostic journey. In your case, the suspicion of Superior Mesenteric Artery (SMA) Syndrome is particularly noteworthy, especially given the anatomical findings that suggest vascular compression of the duodenum. SMA Syndrome occurs when the SMA compresses the third part of the duodenum, often due to a decrease in the angle between the aorta and the SMA, which can lead to gastrointestinal obstruction and symptoms such as vomiting, abdominal pain, and weight loss.


Diagnosis Confirmation
To confirm the diagnosis of SMA Syndrome, imaging studies are crucial. A CT scan can provide valuable information about the angle between the SMA and the aorta, as well as any potential compression of the duodenum. In your case, the reported angle of 23 degrees is indeed indicative of SMA Syndrome, as the normal range is typically between 38° and 56°.
In addition to CT scans, other imaging modalities such as MRI with angiography can be utilized to assess the vascular anatomy without the use of contrast agents, which is beneficial given your history of allergic reactions to contrast media. MRI can visualize the SMA and its relationship with surrounding structures, providing further confirmation of the diagnosis.


Treatment Options
Surgical intervention is often considered when conservative management fails, especially in cases of significant obstruction. The procedures you underwent, including duodenojejunostomy and pyloroplasty, are aimed at bypassing the obstructed segment of the duodenum. However, it is not uncommon for patients to experience persistent symptoms post-surgery, as the underlying motility issues may not be resolved solely by addressing the anatomical obstruction.

If symptoms persist despite surgical intervention, further evaluation may be warranted. This could include additional gastrointestinal studies to assess motility, such as gastric emptying studies or esophageal manometry, to rule out other functional disorders like gastroparesis or cyclic vomiting syndrome.


Considerations for Further Surgery
The suggestion of additional surgical options, such as fundoplication or vagotomy, should be approached with caution. While these procedures may alleviate some symptoms, they can also lead to complications such as dumping syndrome or altered gastric function. A thorough discussion with a gastroenterologist and a surgeon specializing in complex gastrointestinal disorders is essential to weigh the potential benefits and risks of further surgical intervention.


Nutritional Support
Given the severity of your symptoms and the significant weight loss, nutritional support is critical. Home intravenous (IV) nutrition (TPN) can help maintain your nutritional status while you navigate these challenges. Collaborating with a dietitian who specializes in gastrointestinal disorders can also provide tailored dietary strategies to manage your symptoms and improve your overall health.


Psychological Support
Chronic illness can take a toll on mental health, and it is important to address any psychological distress you may be experiencing. Engaging with mental health professionals, such as psychologists or counselors, can provide coping strategies and emotional support during this challenging time.


Conclusion
In summary, SMA Syndrome is a complex condition that requires a multidisciplinary approach for effective management. Continued collaboration with your healthcare team, including gastroenterologists, surgeons, dietitians, and mental health professionals, is essential to address both the physical and emotional aspects of your condition. If you have further questions or concerns, do not hesitate to reach out to your healthcare providers for guidance tailored to your specific situation.

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