Lateral Tumors and Malignant Adenomas in Colorectal Health - Oncology

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There are laterally developing tumors within the intestine and a malignant intestinal adenoma on the intestinal wall?


My father was found to have a lateral type of developing adenoma in the left colon during a colonoscopy on January 28 of this year.
The report indicated: "A broad-based elevation was observed 36 cm from the anus, with a nodular, smooth surface, approximately 3x3.5 cm in size, and a central shallow depression.
After NS injection, the lesion could be elevated, and spot injections were performed for localization.
No abnormalities were noted in the remaining areas.
Due to the large extent of the lesion, it was deemed unsuitable for snare resection or ESD, and surgical treatment was recommended." The gastroenterologist stated that the lateral type developing tumor should be neutral.
Subsequently, the doctor decided to perform a segmental resection of the affected bowel on February 24 using laparoscopic surgery.
During the procedure, the doctor also discovered an adenoma on the bowel's outer wall, stating: "This tumor is at the borderline, as its shape has formed a butterfly-like appearance, and it appears to be at the borderline between benign and malignant.
Therefore, the lymph nodes were also removed.
If the pathology report of the adenoma on the bowel's outer wall is malignant, but the lymph nodes are benign, chemotherapy will not be necessary.
If both are malignant, chemotherapy will be required." The report indicated that the adenoma was malignant, but the lymph nodes were benign.
Therefore, the doctor stated that chemotherapy is not needed, and my father only needs to undergo a colonoscopy every three months for the next two years.

1.
I would like to ask if my father does not need chemotherapy? In the future, if polyps are found during colonoscopy, can they just be removed?
2.
How does the adenoma on the outer wall of the bowel form? Does it develop from the inner wall of the bowel to the outer wall?
3.
Is it possible for the lateral type developing tumor within the bowel to be benign while the adenoma on the outer wall is malignant?
4.
If my father has a malignant tumor in the bowel, does that mean he has colon cancer? What stage is it?

He Tai, 40~49 year old female. Ask Date: 2016/03/05

Dr. Lai Yicheng reply Oncology


Dear Ms.
He,
I have read your letter several times, but I still do not fully understand your content.
I will attempt to answer your questions.
1.
Your father's intestinal malignancy refers to colorectal cancer.
From your letter, I cannot determine the stage; please consult with your physician.
Generally, the staging of cancer must be assessed through surgical pathology and preoperative imaging, such as a CT scan.
2.
Colorectal cancer originates from the innermost layer of the intestine (the mucosa) and progressively invades outward (mucosa → submucosa → muscularis → serosa → peritoneum), while also metastasizing to nearby lymph nodes.
This addresses your questions 2 and 3.
3.
Generally, if the lymph nodes are not affected by cancer cells, adjuvant chemotherapy is not necessary.
However, other factors must be considered, such as the degree of differentiation of the adenocarcinoma cells, the presence of cancer cells in lymphatic vessels, and the presence of cancer cells around nerves.
4.
If polyps are found during a colonoscopy, they can be removed.
Thank you for your inquiry.

Sincerely,
Dr.
Lai Yi-Cheng
Department of Radiation Oncology
Changhua Hospital

Reply Date: 2016/03/05

More Info


Understanding lateral tumors and malignant adenomas in colorectal health is crucial for both patients and their families, especially when faced with complex diagnoses and treatment options. Your father's case involves a lateral-type tumor found in the left colon, which has raised several important questions regarding treatment and prognosis.

1. Chemotherapy Necessity: Based on the information provided, your father does not require chemotherapy at this time. The key factor here is that while the adenoma found on the outer wall of the colon was diagnosed as malignant, the lymph nodes were clear of cancer. This is a significant indicator because the presence of cancer in lymph nodes often dictates the need for chemotherapy. Since the lymph nodes are free of malignancy, the standard approach is to monitor the situation closely rather than initiate chemotherapy. Regular colonoscopies, as recommended by your father's physician, will allow for early detection of any new polyps or changes in existing ones. If any new polyps are found, they can be removed during these procedures.

2. Formation of Lateral Tumors: Lateral tumors, such as the one your father has, can arise from the mucosal layer of the colon and may extend into deeper layers over time. The term "lateral" refers to the growth pattern of the tumor, which can spread sideways rather than growing in a typical polypoidal fashion. This type of tumor can be more challenging to remove completely due to its broad base and infiltrative nature. The adenoma on the outer wall likely developed from the inner lining of the colon and progressed outward, which is a common pathway for colorectal tumors.

3. Possibility of Different Malignancy Levels: It is indeed possible for a lateral-type tumor within the colon to be benign while a separate adenoma on the outer wall is malignant. Tumors can vary significantly in their histological characteristics, and the malignant potential of a tumor can differ based on its location, size, and cellular makeup. In your father's case, the lateral tumor was deemed neutral, while the adenoma was classified as malignant. This highlights the importance of thorough pathological examination and follow-up.

4. Diagnosis of Colorectal Cancer: The presence of a malignant tumor in the colon does indicate that your father has colorectal cancer. The staging of colorectal cancer typically depends on several factors, including the depth of invasion into the bowel wall, the presence of lymph node involvement, and any distant metastasis. Without specific details regarding the depth of invasion and the results of any imaging studies, it is difficult to assign a precise stage. Generally, colorectal cancer is staged from I to IV, with Stage I being localized and Stage IV indicating advanced disease with distant spread. Your father's oncologist or gastroenterologist will be able to provide more specific staging information based on the surgical pathology report and any imaging studies performed.

In summary, your father's situation requires careful monitoring through regular colonoscopies, and the absence of lymph node involvement is a positive sign. Understanding the nature of the tumors and their potential for malignancy is essential for managing his health moving forward. It is advisable to maintain open communication with his healthcare team to address any concerns and to ensure that he receives appropriate follow-up care.

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