Can Antibiotics Affect Birth Control Pills? Your Questions Answered - Obstetrics and Gynecology

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Birth control pills and antibiotics?


Hello Dr.
Huang, I have been taking Yojie for six months.
I had an appointment on Monday, and my gynecologist prescribed two medications: Panamax (generic name: Acetaminophen) and Dolc FC (generic name: Pipemidic Acid).
I have taken them three times, and I had unprotected intercourse on February 22.
Is there a possibility that I could be pregnant? Thank you for your help.

Meimei, 30~39 year old female. Ask Date: 2017/02/23

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I have been taking Yuji for six months, and on Monday, my gynecologist prescribed two medications: Panamax (generic name: Acetaminophen) and Dolc FC (generic name: Pipemidic Acid).
I have taken three doses, and I had unprotected intercourse on February 22.
Is there a possibility of pregnancy?
Answer: The pharmacological action of Pipemidic Acid is that it inhibits bacterial DNA replication, exhibiting bactericidal properties.
It has strong antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, and Vibrio cholerae, but it has little effect on Streptococcus species and anaerobic bacteria.
It is used to treat conditions such as pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, otitis media, dysentery, and sinusitis caused by these bacteria.
Acetaminophen (also known as Paracetamol, abbreviated as APAP) is a widely used over-the-counter analgesic and antipyretic medication.
It is commonly used to relieve headaches and various mild to moderate pains and is a component of many cold medications.
When used in conjunction with opioid analgesics, acetaminophen can help alleviate severe pain, such as postoperative pain and cancer pain.
Although acetaminophen can be used to treat inflammatory pain, it is not classified as a non-steroidal anti-inflammatory drug (NSAID) due to its very weak anti-inflammatory effects.
It is not related to pregnancy.

Reply Date: 2017/02/23

More Info


Antibiotics and their potential effects on birth control pills have been a topic of concern for many individuals using hormonal contraceptives. The interaction between antibiotics and birth control pills can vary depending on the specific antibiotic used. Most commonly prescribed antibiotics do not significantly affect the efficacy of birth control pills, but there are exceptions.

The primary concern arises with antibiotics that can alter the gut flora, which may affect the metabolism of the hormones in birth control pills. For instance, rifampin and rifabutin, which are used to treat tuberculosis and certain bacterial infections, are known to decrease the effectiveness of hormonal contraceptives. However, the antibiotics you mentioned—Panamax (acetaminophen) and Dolc FC (pipemidic acid)—are not typically associated with reduced effectiveness of birth control pills.

Acetaminophen is a pain reliever and fever reducer, while pipemidic acid is an antibiotic that is used to treat urinary tract infections. Neither of these medications is known to interfere with the hormonal mechanisms of birth control pills. Therefore, if you have been taking your birth control pills consistently and correctly, the likelihood of becoming pregnant is low, even after having unprotected intercourse.

It is essential to remember that while most antibiotics do not affect birth control pills, individual responses can vary. If you are ever prescribed a new medication and are concerned about its interaction with your contraceptive method, it is always best to consult with your healthcare provider for personalized advice.

In your case, since you have been taking the birth control pill "Yue Ji" consistently for six months and have only taken the antibiotics for a short period, it is unlikely that you would become pregnant from the unprotected intercourse on February 22. However, if you have any concerns about potential pregnancy or if you experience any unusual symptoms, it would be prudent to take a pregnancy test or consult your healthcare provider for further guidance.

In addition to understanding the interactions between antibiotics and birth control pills, it is also important to consider other factors that can affect contraceptive efficacy, such as missed doses, gastrointestinal issues (like vomiting or diarrhea), and the timing of taking the pill. Always ensure that you are following the instructions provided by your healthcare provider regarding the use of both your contraceptive method and any additional medications.

In summary, based on the medications you mentioned, it is unlikely that you would experience a reduced effectiveness of your birth control pill. However, if you have any lingering concerns or questions, do not hesitate to reach out to your healthcare provider for clarification and peace of mind.

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