Priligy: Dosage, Effectiveness, and Safety Concerns

Q: Priligy: Dosage, Effectiveness, and Safety Concerns

Hello： 1. <br>Please consult the physician who prescribed you Priligy regarding its usage. <br>In my personal opinion, I do not recommend increasing the dosage, as Priligy is a relatively new medication (approved in 2014), and we still need to observe whether there are any long-t

Concerns Regarding the Use of "Priligy" for Treating Premature Ejaculation

1.
Can I increase the dosage of Priligy to three tablets (90mg) at once? Based on my previous experiences with 30mg and 60mg, I haven't felt any side effects (no dizziness, no pain, no lack of concentration, and no drowsiness).
Therefore, I would like to try taking three tablets of Priligy at once, but I'm unsure if it would harm my body.
2.
I've heard that before the introduction of Priligy, patients with premature ejaculation could use Clomipramine to delay ejaculation, but Clomipramine can damage brain nerves.
I'm concerned about whether Priligy could also harm brain nerves.
3.
Is there a recommended number of attempts to try Priligy? For instance, if I try it five times without any effect, should I stop taking it? Is there a specific number of attempts suggested?
4.
While searching for information about Priligy online, I came across a suggestion to take one tablet each week, meaning taking it once every seven days.
What is the correct way to use Priligy? Should it be taken before sexual activity, or is it better to take it once a week?
5.
If I engage in sexual activity every few days and take one tablet each time, will taking 30mg of Priligy frequently still be effective? Or will it lead to the body developing resistance to the medication more quickly, potentially making the situation worse?

Niming, 30~39 year old female. Ask Date: 2017/06/01

Dr. Du Shixi reply Urology

Hello: 1.
Please consult the physician who prescribed you Priligy regarding its usage.
In my personal opinion, I do not recommend increasing the dosage, as Priligy is a relatively new medication (approved in 2014), and we still need to observe whether there are any long-term side effects, since most reported side effects occur within a few hours, and the long-term effects are not fully understood.
2.
I suggest that if you do not see significant results after 3-4 uses, you should discontinue its use (the manufacturer recommends up to 6 uses).
3.
The manufacturer suggests taking the medication approximately 1 to 3 hours before sexual activity.
4.
The manufacturer states that the recommended maximum dosing frequency is once every 24 hours (which is considered safe), but since there are many causes of premature ejaculation, it is advisable to consult a specialist in sexual health at a hospital for a more thorough evaluation.

Reply Date: 2017/06/01

More Info

Priligy, known generically as dapoxetine, is a medication specifically designed for the treatment of premature ejaculation (PE) in men. It is a selective serotonin reuptake inhibitor (SSRI) that works by increasing serotonin levels in the brain, which helps to delay ejaculation. Understanding its dosage, effectiveness, and safety concerns is crucial for anyone considering or currently using this medication.

Dosage and Administration
The typical starting dose of Priligy is 30 mg, taken 1 to 3 hours before sexual activity. If the 30 mg dose is well tolerated but not effective, the dose may be increased to 60 mg. However, it is not recommended to exceed 60 mg in a single dose. Taking more than the recommended dose can increase the risk of side effects without necessarily improving efficacy. Your inquiry about taking 90 mg (three 30 mg tablets) at once is concerning; such a high dose is not advised and could lead to serious side effects, including cardiovascular issues, dizziness, and other adverse reactions.

Effectiveness
The effectiveness of Priligy can vary significantly among individuals. While some may experience substantial improvements in their ability to delay ejaculation, others may find little to no benefit. The fact that you experienced only a slight improvement when increasing the dose to 60 mg suggests that this medication may not be the right fit for you. It is essential to give the medication a fair trial, typically around 4 to 6 doses, to assess its effectiveness. If you find that after several attempts (e.g., 5 doses) it does not work for you, it may be time to consult your healthcare provider about alternative treatments.

Safety Concerns and Side Effects
Priligy is generally well tolerated, but like all medications, it can have side effects. Common side effects include nausea, headache, dizziness, and diarrhea. Serious side effects are rare but can occur. Your concern about potential neurological damage from Priligy is understandable, especially given the history of other medications like clomipramine (克憂果) that have been associated with such risks. However, Priligy is not known to cause neurological damage when used as directed.

Usage Frequency
Priligy is intended for on-demand use, meaning it should be taken before sexual activity rather than on a daily basis. If you have frequent sexual encounters (e.g., every few days), it is acceptable to take it as needed. However, taking it too frequently may lead to tolerance, where the medication becomes less effective over time. It is crucial to follow your healthcare provider's guidance regarding frequency and dosage.

Conclusion
In summary, Priligy can be an effective treatment for premature ejaculation, but it is not suitable for everyone. Increasing the dose beyond the recommended levels is not advisable and could pose health risks. If you find that the medication is not working for you after a reasonable trial period, consult your healthcare provider for alternative options. Always prioritize safety and follow prescribed guidelines to ensure the best outcomes for your health.

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