Eye Health Supplements: Key Considerations and Dosage Guidelines - Nutrition

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Nutritional supplement consultation


Hello, Nutritionist: I would like to consult you regarding eye health supplements.
I purchased an eye care "product" that does not list vitamin A as an additive in the ingredient list, but it contains beta-carotene (the dosage is not specified).
The nutritional label indicates vitamin A at 150 micrograms RE (500 IU) and marigold extract at 25 mg (10% lutein), with a recommended daily intake of 2 tablets.
I have the following questions:
1.
Are there any adverse effects to be aware of with long-term consumption of this supplement? For example, for a housewife who is frequently exposed to cooking fumes, should she be particularly cautious about the beta-carotene in this supplement affecting her health? Would you recommend reducing the daily intake to one tablet?
2.
The vitamin A content per tablet is 500 IU, which I calculated to be approximately 0.9 mg of beta-carotene.
Is this conversion accurate? (I have found varying conversion standards on multiple websites...) Thank you!

ziya, 20~29 year old female. Ask Date: 2018/11/01

Dr. Cai Xiuwen reply Nutrition


Hello! According to the announcement by the National Health Administration, the Dietary Reference Intakes for Taiwanese (7th edition, revised in 2011) states that high doses of "preformed" vitamin A have significant toxicity.
However, long-term intake of high doses of beta-carotene supplements, aside from causing noticeable yellowing of the skin, does not produce specific symptoms or adverse reactions.
Therefore, the harmful effects and toxicity of vitamin A refer specifically to retinol or retinyl ester forms of vitamin A.
The primary causes of vitamin A toxicity are long-term consumption of large amounts of animal liver, cod liver oil, or high-dose supplements.

3.33 IU of retinol is equivalent to 1 RE microgram, where 1 RE = 1 microgram of retinol = 6 micrograms of beta-carotene = 0.9 milligrams of beta-carotene.
The recommended minimum intake is 300–600 µg/day of retinol or 600–1200 µg/day of beta-carotene.
If an adult consumes 150,000 micrograms or more of vitamin A in a short period, or if a child consumes slightly lower doses than mentioned above, it can lead to acute toxicity symptoms.
Reference: National Health Administration, Dietary Reference Intakes for Taiwanese (7th edition, revised in 2011) - Vitamin A.
This information is provided by Dietitian Tsai Hsiu-Wen from Nantou Hospital, Ministry of Health and Welfare.
Wishing you peace and health!

Reply Date: 2018/11/01

More Info


When it comes to eye health supplements, there are several key considerations and dosage guidelines that you should be aware of, especially if you're considering long-term use. Let's break down your questions and provide some insights based on current medical knowledge.


1. Long-term Use and Potential Side Effects
Long-term consumption of eye health supplements, particularly those containing beta-carotene, can have implications depending on individual health conditions and dietary habits. Beta-carotene is a precursor to vitamin A, and while it is generally considered safe, excessive intake can lead to a condition known as carotenemia, where the skin turns yellow-orange due to high levels of carotenoids in the blood. This condition is harmless but can be concerning for some individuals.

For individuals exposed to high levels of smoke or pollutants, such as those who frequently encounter cooking fumes, it’s essential to consider the overall antioxidant load in the body. While beta-carotene is an antioxidant, it can interact with other compounds in the body. For example, some studies suggest that high doses of beta-carotene may increase the risk of lung cancer in smokers. Therefore, if you are a smoker or frequently exposed to smoke, it may be prudent to limit your intake of beta-carotene supplements and focus on obtaining vitamin A from dietary sources like leafy greens, carrots, and sweet potatoes.

If you are concerned about potential side effects, it may be wise to reduce the dosage to one tablet per day instead of two, especially if you are consuming other sources of beta-carotene in your diet.


2. Conversion of Beta-Carotene to Vitamin A
Regarding the conversion of beta-carotene to vitamin A, your calculation appears to be on the right track, but it’s important to clarify the conversion factors. Generally, the conversion rate of beta-carotene to retinol (the active form of vitamin A) is approximately 12:1, meaning that 12 micrograms of beta-carotene can yield about 1 microgram of retinol.
In your case, if the supplement provides 500 IU of vitamin A, this is equivalent to about 0.15 mg of retinol (since 1 IU of vitamin A is approximately 0.3 micrograms of retinol). To convert this back to beta-carotene, you would need to consider the conversion factor. If you were to assume that the beta-carotene in your supplement is converted at the standard rate, you would need about 1.8 mg of beta-carotene to produce 0.15 mg of retinol.
However, the actual conversion can vary based on individual metabolism, dietary fat intake, and the presence of other nutrients. Therefore, while your conversion may seem correct on a basic level, the actual bioavailability and conversion efficiency can differ.


General Recommendations for Eye Health Supplements
1. Consult a Healthcare Provider: Before starting any new supplement, especially for long-term use, consult with a healthcare provider or a registered dietitian. They can provide personalized advice based on your health history and dietary needs.

2. Balanced Diet: Aim for a balanced diet rich in fruits and vegetables, particularly those high in antioxidants, such as leafy greens, carrots, and citrus fruits. These foods provide a natural source of vitamins and minerals that support eye health.

3. Monitor Symptoms: If you notice any unusual symptoms or changes in your health after starting a supplement, discontinue use and consult a healthcare professional.

4. Consider Comprehensive Eye Care: Supplements can support eye health, but they should complement a comprehensive eye care routine that includes regular eye exams, proper lighting when reading or using screens, and protective eyewear when necessary.

In conclusion, while eye health supplements can be beneficial, it’s crucial to approach them with caution, especially regarding dosage and potential interactions with your lifestyle and dietary habits. Always prioritize a well-rounded diet and consult with healthcare professionals for tailored advice.

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