Consultation on Antioxidant Supplement Dosages for Cancer Prevention

Q: Consultation on Antioxidant Supplement Dosages for Cancer Prevention

Hello： The three items mentioned are all health supplements and not medications, so I cannot provide specific dosage recommendations. <br>Health supplements must be certified by the Ministry of Health and Welfare and can only claim health benefits recognized by the central compet

Health product consultation

Hello, due to multiple direct relatives in my family having cancer, I would like to maintain my health through antioxidants.
Currently, I am taking the following (all single compounds): 1.
N-Acetyl-L-Cysteine (daily dosage: 1200mg) 2.
Rose hips (daily dosage: 1650mg) 3.
Ellagic acid (from Pomegranate Seed) (daily dosage: 1400mg).
I would like to inquire if these dosages are too high and could potentially harm my body.
Thank you.

Julie, 20~29 year old female. Ask Date: 2018/12/04

Dr. Hong Kunyi reply Pharmacology

Hello: The three items mentioned are all health supplements and not medications, so I cannot provide specific dosage recommendations.
Health supplements must be certified by the Ministry of Health and Welfare and can only claim health benefits recognized by the central competent authority.
These products do not possess any medical efficacy.
If you experience any physical discomfort, please seek formal medical channels promptly.
If any advertisement seems too miraculous or appealing, it is essential to "stop, look, and listen": Stop - calmly consider whether there is a genuine need and if it will benefit your health; Look - read the relevant information on the packaging; Listen - consult a physician's advice to make informed choices about products that truly benefit your condition.
Additionally, if you have questions about food, drug, or cosmetic advertisements, you can refer to the Food and Drug Administration's "Illegal Food, Drug, and Cosmetic Advertisement Inquiry System" (website: http://pmds.fda.gov.tw/illegalad/) for guidance in selecting products to protect your health and consumer rights.
Thank you very much for your inquiry.
Here are some websites for your reference regarding these health supplements.
If you have any health issues, please be sure to seek proper medical channels! Wishing you and your family peace and well-being.

1.
N-acetyl cysteine (NAC) is a highly suitable antioxidant as a nutritional supplement.
You can refer to NATURAL: https://thenaturalshop.hk/?p=2459.
2.
Rose Hips have many health benefits; you can refer to: http://foodingoodhealth.blogspot.com/2014/01/rose-hips.html.
3.
Ellagic acid is a natural phenolic antioxidant found in many fruits and vegetables, including blackberries, raspberries, strawberries, cranberries, walnuts, pomegranates, and goji berries.
The anti-proliferative and antioxidant properties of ellagic acid have stimulated research into its potential value.
You can refer to: https://zh.wikipedia.org/wiki/%E9%9E%A3%E8%8A%B1%E9%85%B8.

Reply Date: 2018/12/04

More Info

When it comes to antioxidant supplementation, particularly in the context of cancer prevention, it's essential to approach the subject with a balanced understanding of both the potential benefits and risks associated with high dosages. Your inquiry about the specific dosages of N-Acetyl-L-Cysteine (NAC), rose hips, and ellagic acid is particularly relevant given your family history of cancer.

Understanding Antioxidants
Antioxidants are compounds that help neutralize free radicals—unstable molecules that can cause cellular damage and contribute to the development of various diseases, including cancer. While antioxidants are generally considered beneficial, the relationship between antioxidant supplementation and cancer prevention is complex and not entirely understood.

Dosage Considerations
1. N-Acetyl-L-Cysteine (NAC): At a dosage of 1200 mg per day, NAC is often used for its antioxidant properties and its role in replenishing glutathione, a critical antioxidant in the body. While NAC is generally considered safe at this dosage, excessive intake can lead to gastrointestinal disturbances, and in rare cases, it may cause allergic reactions. It is crucial to consult with a healthcare provider, especially if you have underlying health conditions or are taking other medications.

2. Rose Hips: The dosage of 1650 mg per day is within a reasonable range for rose hips, which are rich in vitamin C and other antioxidants. However, high doses can lead to digestive issues such as diarrhea or stomach cramps. Again, moderation is key, and it's advisable to monitor how your body responds to this supplement.

3. Ellagic Acid: At 1400 mg per day, ellagic acid is known for its antioxidant and anti-inflammatory properties, particularly in fruits like pomegranates. While studies suggest that ellagic acid may have protective effects against certain types of cancer, high doses can sometimes lead to gastrointestinal discomfort.

Potential Risks of High Dosages
While antioxidants can provide health benefits, there is a growing body of evidence suggesting that excessive antioxidant supplementation may not always be beneficial and could potentially be harmful. For instance, high doses of beta-carotene (a type of carotenoid) have been linked to an increased risk of lung cancer in smokers. This phenomenon occurs because, under certain conditions, antioxidants can act as pro-oxidants, promoting oxidative stress rather than alleviating it.

Recommendations
1. Consultation with Healthcare Professionals: Given your family history of cancer, it is crucial to work closely with healthcare professionals, including a physician or a registered dietitian, who can provide personalized advice based on your health status and nutritional needs.

2. Focus on Whole Foods: Instead of relying solely on supplements, consider incorporating a variety of antioxidant-rich foods into your diet, such as fruits, vegetables, nuts, and whole grains. These foods provide a complex array of nutrients that work synergistically to promote health.

3. Regular Monitoring: If you choose to continue with these supplements, regular monitoring of your health and any side effects is essential. Adjustments to dosages may be necessary based on your individual response.

4. Avoiding Over-reliance on Supplements: It's important to remember that while antioxidants can support health, they should not replace conventional medical treatments or preventive measures. Relying solely on supplements can lead to neglecting other critical aspects of health, such as a balanced diet, regular exercise, and routine medical check-ups.

Conclusion
In summary, while the antioxidants you are considering have potential health benefits, it is essential to approach their use with caution, particularly regarding dosages. Consulting with healthcare professionals and focusing on a balanced diet rich in natural antioxidants will provide a more holistic approach to health and cancer prevention. Always prioritize safety and informed decision-making when it comes to supplementation.

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