Managing Vitamin B12 and Other Supplements for Oral Health Issues - Family Medicine

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Medication issues


Hello Doctor, I have been experiencing abnormal oral symptoms and am currently taking medication prescribed by a neurologist to alleviate these symptoms.
This includes Rifampicin 4 mg daily, Zanaflex once before bedtime, and Methylcobalamin capsules 500 mcg three times a day, which is said to supplement Vitamin B12 to improve peripheral neuropathy or anemia.
I would like to ask if I can additionally take the Japanese EXplus vitamins (which contain B1, B6, and B12) or a B-complex multivitamin.
If I were to take extra Vitamin B12, would that pose any issues? Recently, I have developed many ulcers in my mouth and on my tongue—at least over ten.
I visited a clinic, and they suggested it might be due to a bacterial infection or low immunity.
Therefore, I am considering supplementing with other vitamins, but I am concerned about the potential negative effects of excessive Vitamin B12.
Thank you for your assistance, Doctor.

Miss Lin, 40~49 year old female. Ask Date: 2019/08/20

Dr. Ye Qianyu reply Family Medicine


Hello, Miss Lin! Regarding your inquiry about vitamins, vitamin B complex is classified as a water-soluble vitamin, and any excess is generally excreted by the body.
Currently, there have been no reported issues related to excessive vitamin B12.
Oral ulcers typically heal on their own; however, if they persist for more than two weeks, it is advisable to seek further evaluation from a rheumatology and immunology specialist.
During the period of oral ulcers, please avoid spicy, fried, hot, and hard foods, and be mindful of any issues related to ill-fitting dentures.
Thank you for your question, and I wish you a speedy recovery!

Reply Date: 2019/08/20

More Info


Managing vitamin B12 and other supplements can be quite complex, especially when dealing with oral health issues and existing medications. Based on your situation, it’s essential to consider both the benefits and potential risks of supplementing with additional vitamins, particularly vitamin B12, while you are already taking medications prescribed for your oral symptoms.

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in red blood cell formation, neurological function, and DNA synthesis. It is particularly important for individuals with conditions that may lead to deficiencies, such as pernicious anemia or certain gastrointestinal disorders. The body typically absorbs vitamin B12 from animal products, and supplementation can be necessary for those who are vegetarian or have absorption issues.

In your case, you are already taking a vitamin B12 supplement (500 mcg) three times a day, which is a significant amount. The concern about taking additional B12 through EXplus vitamins or a B-complex supplement is valid. However, it is important to note that vitamin B12 is generally considered safe, even at higher doses, because it is water-soluble. This means that excess amounts are usually excreted through urine rather than stored in the body. There is currently no established upper limit for vitamin B12 intake, and toxicity is rare.

That said, the presence of multiple oral ulcers and your ongoing symptoms warrant careful consideration. Oral ulcers can be caused by various factors, including nutritional deficiencies, immune system issues, and infections. Since you mentioned that a clinic suggested a possible bacterial infection or low immunity, it may be beneficial to focus on addressing these underlying issues rather than solely increasing vitamin intake.

In terms of managing your oral health, here are some recommendations:
1. Consult Your Healthcare Provider: Before adding any new supplements, including EXplus vitamins or a B-complex, it’s crucial to discuss this with your healthcare provider. They can evaluate your current medications and health status to determine the best course of action.

2. Monitor Symptoms: Keep track of your oral symptoms, including the number and severity of ulcers. If they persist beyond two weeks or worsen, further evaluation by a specialist, such as a rheumatologist or an oral health expert, may be necessary.

3. Dietary Considerations: Focus on a balanced diet rich in vitamins and minerals. Foods high in vitamin B12 include meat, fish, dairy products, and fortified cereals. Incorporating these into your diet may help improve your overall vitamin levels without the need for excessive supplementation.

4. Avoid Irritants: During this time, avoid spicy, acidic, or abrasive foods that may further irritate your mouth. Staying hydrated and maintaining good oral hygiene can also support healing.

5. Consider Other Supplements: If you are concerned about your overall vitamin intake, consider a multivitamin that does not exceed the recommended daily allowance for B12. This can help ensure you are getting a balanced intake of other essential nutrients without the risk of excessive B12.

6. Alternative Forms of B12: If you are worried about absorption issues due to your medications, discuss with your doctor the possibility of using different forms of B12 supplementation, such as sublingual tablets or injections, which may be more effective for some individuals.

In conclusion, while it is generally safe to take additional vitamin B12, especially given its water-soluble nature, your specific health situation requires a tailored approach. Collaborating closely with your healthcare provider will ensure that you manage your vitamin intake effectively while addressing your oral health concerns.

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