Does Using Erectile Dysfunction Medication Raise PSA Levels? - Urology

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Does medication for sexual enhancement increase PSA test values?


My PSA levels have been consistently between 6 and 10, and I have undergone two biopsies without any tumor cells being found.
There is an enlargement of the prostate, but my urination is relatively normal.
However, I have experienced a decline in sexual function and require medication to assist with sexual activity.
Does frequent use of erectile dysfunction medication increase PSA test levels?

kk, 60~69 year old female. Ask Date: 2020/05/04

Dr. Du Shixi reply Urology


Hello: As far as I know, sexual activity can elevate PSA levels, but only for a few days and the impact is minimal.
Therefore, it is advisable to avoid sexual activity before undergoing a PSA test.
Wishing you good health.

Reply Date: 2020/05/04

More Info


Erectile dysfunction (ED) medications, such as phosphodiesterase type 5 inhibitors (e.g., Viagra, Cialis), are commonly prescribed to help men achieve and maintain an erection. However, the relationship between these medications and prostate-specific antigen (PSA) levels is a topic of interest, especially for men who are monitoring their PSA levels due to concerns about prostate health.

To address your question directly: current evidence suggests that the use of erectile dysfunction medications does not significantly raise PSA levels. While sexual activity, including ejaculation, can lead to a temporary increase in PSA levels, the effect of ED medications on PSA is not well-documented. The transient increase in PSA levels due to sexual activity typically resolves within a few days. Therefore, it is generally recommended to avoid sexual activity for 24-48 hours before a PSA test to ensure more accurate results.

In your case, with a PSA level consistently between 6-10 and previous biopsies showing no cancer, it is important to continue monitoring your PSA levels as advised by your healthcare provider. The presence of benign prostatic hyperplasia (BPH) or prostate enlargement can also contribute to elevated PSA levels. This condition is common in older men and can lead to symptoms such as urinary frequency, urgency, and difficulty in urination, which you mentioned are not severely affecting you at this time.

Moreover, factors other than prostate cancer can influence PSA levels, including prostatitis (inflammation of the prostate), recent medical procedures (like a digital rectal exam or prostate massage), and even certain physical activities (like cycling). Therefore, it is crucial to consider these factors when interpreting PSA results.

Regarding the use of ED medications, while they may not directly affect PSA levels, they can have an indirect impact on your overall prostate health. For instance, maintaining sexual function can contribute to psychological well-being and quality of life, which are important aspects of health management in men with prostate concerns.

If you have concerns about your PSA levels or the implications of using ED medications, it is advisable to discuss them with your healthcare provider. They can provide personalized recommendations based on your medical history, current health status, and any other medications you may be taking. Regular follow-up and monitoring are essential, especially given your history of elevated PSA levels and the need for ongoing surveillance.

In summary, while erectile dysfunction medications are unlikely to raise PSA levels significantly, it is essential to maintain open communication with your healthcare provider regarding all aspects of your health, including sexual function and prostate health. Regular monitoring and a comprehensive approach to your health will help ensure that any potential issues are addressed promptly and effectively.

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