Abnormal Blood Test Results in Cancer Survivors - Oncology

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Abnormal blood test results!


Hello, Doctor.
Thank you for taking the time to answer our questions.
My mother has a medical history of being diagnosed with stage II colorectal cancer in March 2019.
After surgery, she did not undergo any treatment and returned home to rest, with regular follow-ups showing normal results.
Recently, she has been experiencing dizziness, which led to a blood test.
She has been a vegetarian (ovo-lacto vegetarian) for about 30 years.
Her blood pressure and heart rate are generally low; on the morning of August 16, her blood pressure was 114/74 and her heart rate was 54.
From August 14 to August 15, she experienced significant dizziness and discomfort, prompting a blood test at a general laboratory, which showed abnormalities as follows: WBC 2780, RBC 3.58, HGB 11.1, HCT 33.1, Platelet 108.
All other values were within normal ranges, as referenced: MCV 92.5, MCH 31.0, MCHC 33.5.
Biochemical tests showed: Glucose 83 (she had eaten something that morning), Creatinine 0.79, Uric acid 4.1, Cholesterol 127, TG 70, HDL-C 41, LDL-C 73, ALT 9.
I would like to ask the doctor: 1.
Should we continue to observe, or should we schedule a follow-up for further detailed examination? 2.
Could the abnormal test results indicate other underlying conditions? 3.
Is there a possibility of cancer recurrence?

Yū, 50~59 year old female. Ask Date: 2021/08/17

Dr. Chen Yunfang reply Oncology


Hello: After reviewing the blood test results you mentioned, I believe there is no major concern.
The blood cell counts are slightly low, which does not seem to be related to cancer recurrence.
It appears more like a manifestation of nutritional deficiency.
Individuals who follow a long-term vegetarian diet may have slight deficiencies compared to those with a completely balanced diet.
I would recommend giving her a multivitamin (such as Centrum or Kirkland) and increasing her intake of dairy protein products.
Thank you for your inquiry.

Reply Date: 2021/08/17

More Info


Understanding abnormal blood test results, especially in cancer survivors, is crucial for ongoing health management. In your mother's case, the recent blood test results indicate several abnormalities that warrant careful consideration.

1. Understanding the Blood Test Results:
- The white blood cell (WBC) count of 2780 cells/µL is below the normal range (typically 4000-10000 cells/µL), indicating leukopenia. This could suggest a compromised immune system, which may be due to various factors, including nutritional deficiencies, bone marrow issues, or the effects of previous cancer treatments, even if she has not undergone treatment recently.

- The red blood cell (RBC) count of 3.58 million cells/µL, hemoglobin (HGB) of 11.1 g/dL, and hematocrit (HCT) of 33.1% are also below normal levels, indicating anemia. Anemia can result from several causes, including nutritional deficiencies (such as iron, vitamin B12, or folate), chronic disease, or bone marrow suppression.

- The platelet count of 108,000 cells/µL is also low (normal range is typically 150,000-450,000 cells/µL), which can lead to increased bleeding risk.

2. Next Steps:
- Given these abnormal results, it is advisable to schedule a follow-up appointment with her healthcare provider. They may recommend further tests to determine the underlying cause of these abnormalities. This could include additional blood tests (such as a complete blood count with differential, reticulocyte count, and iron studies), bone marrow biopsy, or imaging studies if indicated.

- Monitoring her symptoms is also crucial. The episodes of dizziness could be related to anemia or low blood pressure, especially considering her history of low blood pressure and heart rate.

3. Potential Causes of Abnormal Results:
- The abnormalities in her blood tests could be due to several factors, including nutritional deficiencies, chronic conditions, or even the potential for recurrence of cancer. Given her history of colorectal cancer, it is essential to rule out any recurrence or metastasis, especially if she presents with new or worsening symptoms.

- Nutritional deficiencies are particularly relevant since she has been a vegetarian for over 30 years. It would be beneficial to assess her dietary intake to ensure she is receiving adequate nutrients, particularly iron, vitamin B12, and folate.

4. Concerns About Cancer Recurrence:
- While the abnormal blood test results could raise concerns about the possibility of cancer recurrence, it is essential to approach this with caution. Many benign conditions can cause similar blood abnormalities. However, given her history, it is prudent to discuss these concerns with her oncologist, who may recommend surveillance imaging or other diagnostic tests to rule out recurrence.

In summary, your mother’s abnormal blood test results require further evaluation. It is essential to consult her healthcare provider for a comprehensive assessment and to determine the appropriate next steps. Regular monitoring and open communication with her medical team will be vital in managing her health and addressing any potential issues early on.

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