Abnormal Pap Smear Results: HPV Testing and Next Steps - Obstetrics and Gynecology

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Abnormal Pap smear results?


Hello Doctor: I recently had a Pap smear at the clinic, and the results were abnormal with a score of 7.
If further testing is needed, including HPV testing and colposcopy, can I choose one of the two? Additionally, given my current situation, is it still effective to receive the cervical cancer vaccine? Thank you for your response!

Mo, 30~39 year old female. Ask Date: 2021/09/08

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, you should undergo a colposcopy with cervical biopsy.
As for the HPV vaccine, it is effective only if you are not already infected with HPV.
Wishing you good health.

Reply Date: 2021/09/08

More Info


When you receive an abnormal Pap smear result, such as a score of 7, it indicates that there are significant changes in the cervical cells that could potentially lead to cervical cancer. In this case, further evaluation is necessary to determine the underlying cause and to establish an appropriate management plan. The two common follow-up tests are HPV (Human Papillomavirus) testing and colposcopy.

HPV testing is crucial because it helps identify whether the abnormal cells are associated with high-risk HPV types, which are known to contribute to the development of cervical cancer. If the HPV test is positive for high-risk types, it suggests a higher likelihood of significant cervical disease. On the other hand, colposcopy is a procedure that allows the doctor to closely examine the cervix using a special magnifying instrument. During this procedure, the physician may also take biopsies of any suspicious areas for further pathological examination.

Regarding your question about whether you can choose one of the two tests, it is generally recommended to undergo both tests if your Pap smear result is significantly abnormal. The combination of HPV testing and colposcopy provides a more comprehensive understanding of your cervical health and helps guide the next steps in management. If you only choose one, you may miss critical information that could affect your treatment options.

As for the HPV vaccine, it is important to note that it is most effective when administered before exposure to the virus, typically before the onset of sexual activity. However, even if you have already been exposed to HPV, the vaccine can still provide protection against other strains of the virus that you may not have encountered yet. Therefore, receiving the HPV vaccine is still beneficial, as it can help prevent future infections with high-risk HPV types that could lead to cervical cancer.

In summary, if you have received an abnormal Pap smear result, it is advisable to follow up with both HPV testing and colposcopy. This dual approach will provide a clearer picture of your cervical health and help determine the most appropriate course of action. Additionally, getting the HPV vaccine can still be a valuable preventive measure, even if you have already tested positive for HPV or have had abnormal Pap results. Always consult with your healthcare provider to discuss your specific situation and to make informed decisions regarding your health.

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