Does Early Pregnancy or Inflammation Affect Pap Smear Results? - Obstetrics and Gynecology

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Does performing a Pap smear during early pregnancy affect the results?


Hello, doctor.
I went to the gynecology clinic on July 6 and confirmed that I am 5 weeks and 6 days pregnant (the ultrasound showed 5 weeks and 2 days).
Before the ultrasound, I had a Pap smear, and the doctor informed me that there was an increased amount of discharge and some inflammation.
I was given a suppository at that time.
Later, the report came back abnormal, and yesterday, July 14, I returned to review the Pap smear report, which indicated a score of 7 (CIN1).
Could the inflammation during early pregnancy or at the time of the Pap smear affect the interpretation of the Pap test results?

Miss Lin, 30~39 year old female. Ask Date: 2022/07/15

Dr. Chen Zhiyu reply Obstetrics and Gynecology


Regarding your concerns, here is a summary of the response: The Pap smear involves collecting exfoliated cells from the cervix and is not significantly affected by pregnancy.
Based on your Pap smear results, it is advisable to discuss further management with your treating physician as soon as possible.
Thank you for your inquiry, and I wish you health and happiness.

Reply Date: 2022/07/15

More Info


Early pregnancy and inflammation can indeed affect the results of a Pap smear. The Pap smear, or Pap test, is a procedure used to screen for cervical cancer and other abnormalities in the cervix. It involves collecting cells from the cervix and examining them under a microscope. Several factors can influence the accuracy and interpretation of the results, including hormonal changes, inflammation, and the presence of infections.

During early pregnancy, hormonal fluctuations occur, particularly increases in estrogen and progesterone. These hormonal changes can lead to alterations in the cervical cells, making them appear different than they would in a non-pregnant state. This can sometimes result in atypical cells being detected, which may not necessarily indicate a serious problem but rather a response to the pregnancy itself.

Additionally, inflammation in the cervix, which can be caused by infections or other irritants, can also affect Pap smear results. Inflammation can lead to changes in the cervical cells, resulting in a higher likelihood of abnormal findings. In your case, the presence of increased discharge and inflammation noted during the examination may have contributed to the abnormal Pap result, specifically the CIN1 classification.

CIN1, or cervical intraepithelial neoplasia grade 1, indicates that there are some abnormal cells present, but it is generally considered a low-grade lesion. In many cases, CIN1 lesions can resolve on their own without treatment, especially in younger women or those who are pregnant. The fact that you are in the early stages of pregnancy may further complicate the situation, as many healthcare providers prefer to monitor rather than intervene during pregnancy unless there are significant concerns.

It is essential to follow up with your healthcare provider regarding the abnormal Pap smear results. They may recommend additional monitoring or repeat Pap tests after your pregnancy, as the changes observed may resolve postpartum. In some cases, a colposcopy may be suggested to further evaluate the cervical cells, especially if there are concerns about the persistence of abnormal cells.

In summary, early pregnancy and inflammation can indeed influence Pap smear results, leading to potential misinterpretations. It is crucial to maintain open communication with your healthcare provider, who can guide you through the necessary steps and ensure that both your health and the health of your pregnancy are monitored closely. Regular prenatal care and follow-up screenings will help manage any potential risks and provide peace of mind as you progress through your pregnancy.

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