Struggling with Antidepressants: My Experience with Side Effects and Hope - Psychiatry

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I'm sorry to hear that you're feeling this way. It's really important to talk to someone who can help you, such as a mental health professional?


At first, I thought this medication was miraculous.
Usually, antidepressants take two to three weeks to show effects, but after taking the first pill of Wellbutrin, I noticed a significant improvement.
I truly believed I had found a lifeline and thought I could live a normal life.
However, after two to three days, I began to experience symptoms similar to social anxiety.
After seven to eight days, I started to have a loss of appetite and nausea (note: I had a loss of appetite but still felt very hungry).
I even experienced hypersomnia; I was so hungry that I couldn't finish a bowl of instant noodles.
Not only could I not finish it, but I also started to feel nauseous and wanted to vomit.
Fortunately, the MESYREL I took before bed had a sedative effect, and I also took some gastrointestinal medication, which has helped a lot.
I initially thought Wellbutrin had great effects, but the side effects were so severe.
Is it really impossible to find a medication that suits me? Sometimes I feel like it would be better to just end it all rather than worry about which medication to switch to.

Jianyu, 20~29 year old female. Ask Date: 2003/10/13

Dr. Chen Wenke reply Psychiatry


Hello Swordfish: From your description, it seems there is some misunderstanding regarding medications.
Generally, medications like Prozac (Fluoxetine) do take about three weeks to show significant antidepressant effects; taking it for just one day is unlikely to yield results.
In the initial 1-2 weeks, some patients may experience gastrointestinal discomfort as a side effect, and some may feel a bit drowsy, but this is usually not severe and tends to diminish after about a week.
There are now many types of antidepressants available, so if you cannot tolerate the side effects of Prozac, there are other options to consider, and you need not worry too much.
Wishing you well.

Reply Date: 2003/10/13

More Info


It sounds like you are going through a very challenging time with your mental health and the medications you are taking. It's important to acknowledge the struggles you are facing, especially when it comes to managing the side effects of antidepressants. Your experience is not uncommon, and many individuals dealing with depression and anxiety encounter similar issues when starting or adjusting their medication.

Antidepressants, such as SSRIs (Selective Serotonin Reuptake Inhibitors) like Prozac (fluoxetine) or Zoloft (sertraline), typically take a few weeks to show their full effects. However, some people may experience immediate changes in their mood or anxiety levels, which can be misleading. Initially, you might feel a sense of relief or improvement, but as you noted, side effects can emerge that complicate the situation. Common side effects of antidepressants include nausea, changes in appetite, sleep disturbances, and increased anxiety or social withdrawal. These can be particularly distressing, especially when you are already dealing with the symptoms of depression.

It's crucial to communicate openly with your healthcare provider about the side effects you are experiencing. They can help you navigate these challenges, whether that means adjusting your dosage, switching to a different medication, or adding adjunctive treatments to help manage the side effects. For example, if you are experiencing significant nausea or gastrointestinal issues, your doctor may prescribe medication to help alleviate those symptoms.

You mentioned feeling hopeless and contemplating extreme measures due to the frustration with finding the right medication. It's vital to remember that there is hope, and many people do find relief from their symptoms with the right treatment plan. It may take time and patience, but working closely with your healthcare provider can lead to a more manageable situation.

In addition to medication, consider incorporating other therapeutic approaches into your treatment plan. Cognitive Behavioral Therapy (CBT) has been shown to be effective for many individuals with depression and anxiety. It can help you develop coping strategies, challenge negative thought patterns, and improve your overall emotional resilience. Mindfulness practices, such as meditation and yoga, can also provide additional support by helping you manage stress and anxiety.

It's understandable to feel overwhelmed and frustrated, but please know that you are not alone in this journey. Many individuals have faced similar struggles and have found ways to cope and thrive. Surround yourself with supportive friends and family, and don't hesitate to reach out for professional help when needed. Your mental health is a priority, and taking steps to care for yourself is essential.

Lastly, if you ever feel that your safety is at risk or that you are in crisis, please seek immediate help. Contact a mental health professional, a crisis hotline, or go to the nearest emergency room. Your life is valuable, and there are people who want to help you through this difficult time.

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