Effective Treatments for Knee Degeneration: Beyond Pain Relief - Orthopedics

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Knee degeneration


Hello Doctor,
I have a question.
My knee hurts, and after an X-ray, it was diagnosed as degenerative.
The doctor only prescribed painkillers and advised me to do quadriceps exercises (lifting my leg at a 45-degree angle while lying down).
I have been doing this for over six months and also taking glucosamine, but the improvement has been very limited.
Recently, I heard about regenerative treatment (injections of glucose) and have had three sessions, but there hasn't been a noticeable effect.
I still experience some pain after standing for a long time (it's a sharp pain, but the location is not fixed).
It's not extremely painful, but sometimes when I bend my knee, I feel some tightness above the knee, which goes away after straightening and bending again.
Although the doctors say my condition is not severe, my recovery has been minimal.

What other treatment options can I explore? Recently, there has been a lot of advertising for a product called "Taiwan Salt Collagen Peptide" endorsed by Guo Ziqian, but I am unsure of its effectiveness and it is quite expensive.
Are there any treatment methods you can recommend? Additionally, I would like to ask if hyaluronic acid injections are solely for lubricating the cartilage.
I have heard that cartilage tissue is similar in composition to hyaluronic acid; is this true? After receiving hyaluronic acid injections, will I need to rely on them for life? If I stop, will my condition worsen? Are there any dietary recommendations or specific brands you would suggest?

Axiang, 40~49 year old female. Ask Date: 2022/10/22

Dr. Shi Guozheng reply Orthopedics


The X-ray indicates that the knee joint has degenerated, so it's important to assess the degree of degeneration.
If it's not severe, it usually improves with medication.
Hyaluronic acid injections can also alleviate pain symptoms, and if improvement is seen, there may be no need for continuous injections.
It's advisable to consult a qualified physician for diagnosis and treatment, as over-the-counter products are typically of health supplement grade and may not provide significant help.

Reply Date: 2022/10/22

More Info


Knee degeneration, often characterized by osteoarthritis, can be a challenging condition to manage, especially when conventional treatments such as pain relief medications and physical therapy yield limited results. Your experience with glucosamine and quadriceps strengthening exercises is common among patients seeking relief from knee pain. However, it is essential to explore a variety of treatment options, as individual responses to therapies can vary significantly.

Firstly, it's important to understand that knee degeneration involves the gradual wear and tear of cartilage, which can lead to pain, stiffness, and decreased mobility. While pain relief medications can help manage symptoms, they do not address the underlying degeneration. Physical therapy, particularly exercises that strengthen the quadriceps, can improve knee stability and function, but as you've noted, these may not always provide sufficient relief.

In recent years, several alternative treatments have gained attention for their potential benefits in managing knee degeneration. One such treatment is platelet-rich plasma (PRP) therapy, which involves injecting a concentration of platelets derived from your blood into the knee joint. PRP contains growth factors that may promote healing and reduce inflammation. Some studies suggest that PRP can provide pain relief and improve function in patients with knee osteoarthritis, although results can vary.

Another option is hyaluronic acid injections, which you mentioned. Hyaluronic acid is a naturally occurring substance in the joint that helps lubricate and cushion the cartilage. While it does not regenerate cartilage, it can provide temporary relief from pain and improve joint function. The effects of hyaluronic acid injections can last from several months to a year, but they are not a permanent solution. Patients often wonder if they will become reliant on these injections; while they can be beneficial, they do not necessarily lead to further degeneration if treatment is paused.

Regarding the use of collagen peptides, such as those found in the product you mentioned, there is some evidence suggesting that oral collagen supplements may support joint health by improving cartilage integrity and reducing pain. However, more research is needed to establish definitive benefits. It's crucial to consult with a healthcare provider before starting any new supplement, especially if you have existing health conditions or are taking other medications.

In addition to these treatments, lifestyle modifications can play a significant role in managing knee degeneration. Maintaining a healthy weight can reduce stress on the knees, and low-impact exercises such as swimming or cycling can help maintain joint mobility without exacerbating pain. Additionally, incorporating anti-inflammatory foods into your diet, such as fatty fish rich in omega-3 fatty acids, fruits, vegetables, and whole grains, may help reduce inflammation and support overall joint health.

Lastly, if you are considering new treatments or therapies, it's advisable to discuss them with your healthcare provider. They can provide guidance based on your specific condition and medical history. If your current treatment plan is not yielding satisfactory results, seeking a second opinion from a specialist in orthopedic medicine or a rheumatologist may also be beneficial. They can offer insights into the latest treatment options and help tailor a plan that addresses your unique needs.

In summary, while pain relief is an essential aspect of managing knee degeneration, exploring a comprehensive approach that includes alternative treatments, lifestyle changes, and possibly dietary supplements may provide a more effective strategy for improving your knee health and overall quality of life.

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