Can Probiotics and Omega-3 Foods Help Manage Ankylosing Spondylitis? - Internal Medicine

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Is taking probiotics or regularly consuming foods rich in omega-3 beneficial for ankylosing spondylitis?


Hello Dr.
Tseng, I am a patient with ankylosing spondylitis, and I have been experiencing symptoms for three and a half years.
Currently, I take two tablets of Celebrex and one tablet of Humira daily to manage my condition.
Although my pain is relatively well controlled, I still experience occasional pain.
Additionally, my inflammatory markers fluctuate (CRP levels sometimes are 0.2, 0.4, but at times they spike to 0.9, 1.0).
I would like to ask the doctor: 1) Can taking probiotics help with my ankylosing spondylitis, or could it potentially have adverse effects? 2) There are many reports online suggesting that omega-3 can effectively combat inflammation, but I am unsure if the inflammation referred to in these reports includes the inflammation associated with ankylosing spondylitis.
Therefore, I would like to ask the doctor if regularly consuming foods rich in omega-3 can improve the inflammatory condition of ankylosing spondylitis.
Thank you, doctor.

Zhong, 20~29 year old female. Ask Date: 2023/03/14

Dr. Zeng Guosen reply Internal Medicine


Online users suggest that omega-3 can combat inflammation, but its effectiveness in improving the inflammatory condition of ankylosing spondylitis is limited; it should only be used as a supplement and cannot be used for treatment.
Probiotics or omega-3 are not expected to have adverse effects on the disease.

Reply Date: 2023/03/14

More Info


Ankylosing spondylitis (AS) is a type of inflammatory arthritis that primarily affects the spine, leading to severe, chronic pain and discomfort. Managing AS often involves a combination of medication, physical therapy, and lifestyle changes, including diet. Your questions regarding the potential benefits of probiotics and omega-3 fatty acids in managing AS are quite relevant, as emerging research suggests that diet can play a significant role in inflammation and overall health.

1. Probiotics and Ankylosing Spondylitis: Probiotics are live microorganisms that can provide health benefits when consumed in adequate amounts. They are often touted for their ability to improve gut health and modulate the immune system. Some studies suggest that probiotics may help reduce inflammation and improve symptoms in various inflammatory conditions, including arthritis. However, the evidence specifically linking probiotics to improvements in ankylosing spondylitis is still limited.
While probiotics may not directly alleviate AS symptoms, they can support gut health, which is increasingly recognized as a crucial factor in managing autoimmune and inflammatory diseases. A healthy gut microbiome can influence systemic inflammation and immune responses. Therefore, incorporating probiotics into your diet could be beneficial, but it is essential to choose high-quality products and consult with your healthcare provider to ensure they are appropriate for your specific situation.

2. Omega-3 Fatty Acids and Inflammation: Omega-3 fatty acids, found in foods like fatty fish (e.g., salmon, mackerel), flaxseeds, chia seeds, and walnuts, are well-known for their anti-inflammatory properties. Numerous studies have shown that omega-3s can help reduce inflammation in various conditions, including rheumatoid arthritis and other inflammatory diseases.
In the context of ankylosing spondylitis, some research indicates that omega-3 fatty acids may help lower inflammatory markers, such as C-reactive protein (CRP), which you mentioned fluctuates in your case. While the direct evidence linking omega-3 intake to improved outcomes in AS is still being explored, the general consensus is that increasing omega-3 consumption can be beneficial for managing inflammation and may help alleviate some symptoms associated with AS.

In summary, both probiotics and omega-3 fatty acids have the potential to support your management of ankylosing spondylitis, primarily through their anti-inflammatory effects. However, it is crucial to approach these dietary changes as part of a comprehensive treatment plan that includes your prescribed medications and lifestyle modifications. Always consult with your healthcare provider before making significant changes to your diet or supplement regimen, especially considering your ongoing treatment for AS.
In addition to probiotics and omega-3s, consider incorporating a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, while minimizing processed foods, sugars, and saturated fats. Regular physical activity, stress management, and adequate sleep are also vital components of managing ankylosing spondylitis effectively.

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