Myelocytes in Blood Smears: Should You Be Concerned? - Oncology

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A myelocyte was observed in the blood smear?


I am a student in the medical technology program.
Last month, while observing my own blood smear in a hematology lab, I found a myelocyte.
I went to the hospital for a blood test, and the results showed that everything was within normal ranges.
Today, I observed another myelocyte.
I would like to know if I should be concerned about any underlying condition.

Mr. Huang, 10~19 year old female. Ask Date: 2023/06/06

Dr. Hu Ziren reply Oncology


Sometimes, when the body is in an inflammatory or acute infection stage (such as a viral infection), a small number of immature cells may be found in the peripheral blood.
If the white blood cell count (WBC), hemoglobin (HB), platelet count (PLT), and other classifications are normal, it is recommended to have a follow-up examination in 3 to 6 months.

Reply Date: 2023/06/06

More Info


The presence of myelocytes in a blood smear can indeed raise questions, especially for someone studying medical technology. Myelocytes are immature white blood cells that are typically found in the bone marrow. They are part of the granulocyte lineage, which includes neutrophils, eosinophils, and basophils. In a healthy individual, myelocytes are usually not present in the peripheral blood; their appearance can indicate a response to various physiological or pathological conditions.

In your case, you mentioned observing a myelocyte in your blood smear and subsequently undergoing a blood test that returned normal results. This is an important detail. The presence of a single myelocyte, especially if accompanied by normal white blood cell counts and other hematological parameters, may not necessarily indicate a serious condition. It can occur in situations such as:
1. Physiological Stress or Inflammation: The body can release immature cells into the bloodstream in response to stress, infection, or inflammation. This is a common reaction, and if your overall blood counts are normal, it may not be a cause for concern.

2. Bone Marrow Response: Sometimes, the bone marrow may be stimulated to produce more white blood cells due to an infection or other stimuli, leading to the occasional release of myelocytes into circulation.

3. Transient Findings: It is also possible that the presence of myelocytes is a transient finding that may not have clinical significance, especially if it is isolated and not accompanied by other abnormal findings.

Given that your blood test results were normal, it is reasonable to monitor the situation rather than jump to conclusions about potential diseases. It is advisable to follow up with your healthcare provider, especially if you continue to see myelocytes in future blood smears or if you develop any symptoms such as fatigue, fever, or unusual bruising.

In terms of further action, it might be beneficial to repeat the blood smear in a few months to see if the finding persists. If myelocytes continue to appear, or if you experience any concerning symptoms, further evaluation may be warranted. This could include more comprehensive blood tests, bone marrow biopsy, or consultation with a hematologist.

In summary, while the presence of myelocytes can be concerning, in the context of normal blood tests and without accompanying symptoms, it may not indicate a serious condition. Continuous monitoring and communication with your healthcare provider will be key in ensuring your health and addressing any potential issues that may arise.

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