Can You Take Fish Oil and B Vitamins with Salazopyrin? - Internal Medicine

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Ankylosing Spondylitis


Hello Doctor, I would like to ask a question.
I am a patient with ankylosing spondylitis and I am currently taking Celebrex and Voltaren.
Recently, I want to buy fish oil and B vitamins.
Can I take B vitamins and fish oil together with Celebrex, or should I separate them by a certain amount of time before taking the supplements? Thank you for your response, Doctor.

Nike, 10~19 year old female. Ask Date: 2023/11/21

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
Vitamin B complex and fish oil can be taken together with Salazopyrin.
If you have concerns, you may also separate them by an hour.
This is a message from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare, caring for you.

Reply Date: 2023/11/21

More Info


When considering the simultaneous use of fish oil, B vitamins, and Salazopyrin (sulfasalazine), it is important to understand the potential interactions and the overall health implications. Salazopyrin is commonly prescribed for inflammatory bowel diseases and conditions like ankylosing spondylitis, and it works by reducing inflammation in the body.
Based on the information provided, it is generally considered safe to take fish oil and B vitamins alongside Salazopyrin. Fish oil is rich in omega-3 fatty acids, which are known for their anti-inflammatory properties. This can be particularly beneficial for individuals with inflammatory conditions, as omega-3s may help reduce inflammation and improve joint health. B vitamins play a crucial role in energy metabolism and can support overall health, especially in individuals who may be experiencing fatigue due to chronic conditions.

However, while there are no direct contraindications for taking these supplements together, it is advisable to space them out slightly to optimize absorption and minimize any potential gastrointestinal discomfort. A common recommendation is to take Salazopyrin and then wait about an hour before taking fish oil or B vitamins. This allows the body to absorb the medication effectively without interference from the supplements.

It is also important to consider the dosage of each supplement. For fish oil, typical dosages range from 1,000 mg to 3,000 mg per day, depending on individual health needs and dietary intake of omega-3s. B vitamins are usually taken in a B-complex formulation, which can vary in dosage, so it's essential to follow the recommended guidelines on the product label or those provided by a healthcare professional.

Moreover, if you are taking other medications or have underlying health conditions, it is crucial to consult with your healthcare provider before adding any new supplements to your regimen. They can provide personalized advice based on your specific health situation and ensure that there are no potential interactions with your current medications.

In summary, taking fish oil and B vitamins with Salazopyrin is generally safe and may even provide additional health benefits, particularly for managing inflammation. Just remember to space out the timing of the supplements and consult with your healthcare provider for tailored advice. This approach will help ensure that you are maximizing the benefits of your treatment while minimizing any risks.

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