Can You Mix Oral Isotretinoin from Different Sources?

Oral isotretinoin issues?

Hello Doctor, I previously lived in China for a while and had severe acne.
I visited a local hospital there, and they prescribed oral isotretinoin from a Chinese pharmaceutical company.
After returning to Taiwan, I didn't finish the medication before it ran out.
Then, a dermatologist in Taiwan prescribed the original brand of oral isotretinoin.
Recently, I found the oral isotretinoin I had from China, which is still not expired and has a lot left.
I would like to ask if it is safe to mix both medications? My doctor is a bit difficult to schedule an appointment with, so I am inquiring online first.
The active ingredient is the same, isotretinoin.
Thank you, Doctor.

Niming, 20~29 year old female. Ask Date: 2024/03/19

Dr. Wu Yuxin reply Dermatology

I'm not familiar with oral isotretinoin from China, so I cannot provide you with an answer.
I apologize.

Reply Date: 2024/03/19

More Info

When it comes to mixing oral isotretinoin from different sources, it is essential to approach this matter with caution. Isotretinoin, commonly known as Accutane, is a powerful medication primarily used to treat severe acne. While the active ingredient, isotretinoin, may be the same across different formulations, there are several factors to consider before combining medications from different manufacturers.

1. Variability in Formulations: While the active ingredient may be identical, the inactive ingredients, such as fillers, binders, and preservatives, can vary between different manufacturers. These differences can affect the absorption and efficacy of the medication. For example, some individuals may have sensitivities or allergies to certain inactive ingredients, which could lead to adverse reactions or reduced effectiveness.

2. Dosage Considerations: Isotretinoin is typically prescribed in a specific dosage tailored to the patient's needs, taking into account factors such as weight, severity of acne, and previous treatment history. Mixing medications from different sources could lead to unintentional overdosing or underdosing, especially if the dosages of the two sources differ. This could increase the risk of side effects or reduce the treatment's effectiveness.

3. Side Effects and Monitoring: Isotretinoin is associated with a range of potential side effects, including dry skin, chapped lips, and more severe risks such as liver damage and increased cholesterol levels. When using isotretinoin, regular monitoring by a healthcare provider is crucial. Mixing medications without professional guidance could complicate this monitoring process, making it harder to identify which medication may be causing side effects.

4. Consultation with a Healthcare Provider: Given the complexities involved in using isotretinoin, it is highly advisable to consult with a healthcare provider before mixing medications from different sources. If your dermatologist is difficult to reach, consider seeking advice from another healthcare professional or a pharmacist. They can provide guidance based on your specific situation and help you make an informed decision.

5. Legal and Regulatory Considerations: In some regions, medications may be subject to different regulations and quality control standards. The isotretinoin you obtained in China may not meet the same safety and efficacy standards as the one prescribed in Taiwan. This is another reason to be cautious about mixing medications from different sources.

In summary, while both medications you have contain isotretinoin, it is not advisable to mix them without consulting a healthcare professional. The potential risks associated with variability in formulations, dosage discrepancies, and side effects warrant careful consideration. Always prioritize your health and safety by seeking professional advice before making any changes to your medication regimen.

Similar Q&A

Can You Safely Combine Oral A Acid with Multivitamins?

(1) Currently, I am taking oral isotretinoin 20mg every 3 to 4 days. (2) Before starting isotretinoin, I was taking a multivitamin (Centrum for Women), which contains 600mcg of vitamin A per tablet. (3) Since I am concerned about the multivitamin going to waste, I would like to i...

Dr. Wu Yuxin reply Dermatology
Vitamin A acid and vitamin A are not the same.

Can Oral Isotretinoin and Hepatitis Medication Be Taken Together?

Hello, Pharmacist Hou: I am currently taking two medications, oral isotretinoin and Liv52, for a long-term condition (I am a hepatitis carrier, and my liver enzyme levels are around 100, indicating inflammation). The doctor who prescribed Liv52 strictly prohibited me from taking...

Dr. Hou Fangmin reply Pharmacology
Hello Mr. Lin, 1. The use of isotretinoin may lead to adverse reactions such as elevated liver transaminases, triglycerides, or cholesterol, as well as potential teratogenic effects. Liver function should be assessed before treatment and one month after starting therapy, followe...

Can I Take Oral Isotretinoin and Finasteride Together?

Hello, doctor. I previously consulted a physician regarding my acne issues and have been regularly taking oral isotretinoin (Roaccutane) 20mg. Recently, I visited the doctor for my long-standing issue of thinning hair on both sides of my forehead (which was present before taking ...

Dr. Chen Yuemei reply Pharmacology
Hello: The Roaccutane 20mg (active ingredient: Isotretinoin) and Finta (active ingredient: Finasteride) you are taking have been reviewed in the literature, and no interactions between the two have been documented.

Can I Mix AHA with Water for Acne Treatment?

Previously, my doctor prescribed me a 0.1% third-generation retinoid to treat acne. The doctor advised me to use only a pea-sized amount and not to apply too much. However, I find it difficult to spread it evenly over my entire face. Can I mix it with a little water before applyi...

Dr. Wu Yuxin reply Dermatology
You can apply moisturizer first, followed by tretinoin.