Why My Skin Reacted Badly to Tretinoin: A Dermatology Concern - Dermatology

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Why has my skin worsened after using the tretinoin prescribed by my doctor?


Last Wednesday, I visited a dermatologist.
The doctor said I have a lot of acne and comedones, so they prescribed me Tretinoin 0.08% cream to apply.
However, after using it, my skin developed symptoms such as redness, swelling, stinging, and itching.
Every time I wash my face and apply moisturizer, the red and swollen areas become even more painful.
Additionally, the red and swollen areas resemble eczema (since I have had eczema in the past, I feel that the areas that became red and swollen after applying Tretinoin look like eczema).
Is the appearance of these symptoms on my skin after using Tretinoin due to inadequate moisturizing? Should I return for a follow-up appointment? Thank you for your response, doctor!

SWAN, 20~29 year old female. Ask Date: 2005/03/24

Dr. Zheng Lizhen reply Dermatology


Hello: This is a common dermatitis phenomenon associated with the initial use of retinoic acid.
Please discontinue the use of the ointment and return to the outpatient clinic for consultation.
Sincerely, Dr.
Cheng Li-Chen, Dermatology.

Reply Date: 2005/03/24

More Info


When using Tretinoin, a topical retinoid commonly prescribed for acne and other skin conditions, it is not unusual to experience adverse reactions such as redness, irritation, and peeling, especially when first starting the treatment. These symptoms can be exacerbated by environmental factors, skin care routines, and the formulation of products used in conjunction with Tretinoin.


Understanding Tretinoin and Its Effects
Tretinoin works by promoting cell turnover, which helps to prevent clogged pores and reduce acne. However, this increased cell turnover can lead to irritation as the skin adjusts to the medication. Common side effects include:
- Redness: This is a sign of irritation and can occur as the skin becomes more sensitive.

- Stinging or Burning Sensation: This can happen upon application, especially if the skin is not adequately prepared or if too much product is used.

- Dryness and Peeling: As Tretinoin accelerates the shedding of dead skin cells, it can lead to dryness and flaking.


The Role of Moisturizers
Moisturizers play a crucial role in mitigating the side effects of Tretinoin. If your skin is reacting poorly, it may be due to insufficient hydration or the choice of moisturizer. Here are some tips regarding moisturizers when using Tretinoin:
1. Choose the Right Moisturizer: Opt for a gentle, fragrance-free moisturizer that is non-comedogenic. Look for ingredients like hyaluronic acid, glycerin, or ceramides, which help to hydrate and repair the skin barrier.

2. Timing of Application: It is often recommended to apply Tretinoin to clean, dry skin, and then follow up with a moisturizer. Some patients find it beneficial to apply moisturizer first (the "sandwich method") to reduce irritation.

3. Frequency of Use: If you are experiencing significant irritation, consider reducing the frequency of Tretinoin application. Instead of daily use, you might start with every other night or even less frequently until your skin builds tolerance.


Possible Interaction with Other Products
If you are using other products, such as exfoliants or harsh cleansers, these can compound irritation. Ensure that your skincare routine is gentle and avoid using products that can further irritate the skin, such as those containing alcohol or strong acids.


When to Seek Further Medical Advice
If the symptoms persist or worsen, it is advisable to return to your dermatologist. They may suggest:
- Adjusting the Tretinoin Strength: Sometimes a lower concentration can be effective with fewer side effects.

- Alternative Treatments: If Tretinoin is not suitable for your skin, your dermatologist may recommend other acne treatments that may be better tolerated.

- Patch Testing: If you suspect that your moisturizer or other products are causing a reaction, patch testing can help identify irritants.


Conclusion
In summary, while Tretinoin is an effective treatment for acne, it can cause irritation, especially when first introduced. Ensuring proper moisturizing, adjusting application frequency, and being mindful of other products used can help manage these side effects. If you continue to experience discomfort, do not hesitate to consult your dermatologist for tailored advice and potential adjustments to your treatment plan. Your skin's health is paramount, and finding the right balance in your skincare routine is essential for achieving the best results.

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