Post-Medication Sexual Dysfunction: Causes and Solutions - Urology

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Recurrent erectile dysfunction?


I recently got married, but early last year, I suddenly experienced a panic attack while driving.
My psychiatrist prescribed Alprazolam (Xanax) and Paroxetine (Seroxat).
Initially, after starting the medication, I experienced delayed ejaculation, but this gradually improved and returned to normal.
After taking the medication for nearly ten months, I began to taper off in mid-October last year.
The symptoms of panic disorder have since lessened to occasional discomfort, primarily while driving.
However, every time I try to be intimate with my wife, I find that although I want to, I seem unable to achieve an erection.
When I watch my favorite adult films and masturbate, I can achieve an erection, but it feels less firm and lasts a shorter duration than before.
Additionally, I hardly experience morning erections anymore, which used to happen occasionally.
I do have significant work-related stress and have been feeling more fatigued lately.

I don't understand why my sexual function has declined after stopping the medication.
Therefore, I consulted doctors at Chang Gung Memorial Hospital and Chung Hsing Hospital.
The tests showed that my testosterone levels are within the normal range, but slightly lower compared to other men my age.
Chang Gung Hospital prescribed Viagra, but I experienced facial flushing and it took about two hours to take effect, so I only used it twice.

However, perhaps due to the sufficient time off the medication, I experienced a period of normalcy at the beginning of this year, and intimacy with my wife went smoothly.
But in late February, one morning I woke up feeling dizzy and unable to sit up.
I was taken to the emergency room, where the doctor diagnosed me with vertigo caused by inner ear imbalance, the cause of which is unknown but is still related to stress and emotions.
After taking medication, my condition improved, but I still occasionally feel a bit lightheaded.
One of the medications I was prescribed is Diazepam, which is also used for panic, and this has led to a resurgence of sexual dysfunction.
Currently, I only take medication occasionally when I feel particularly dizzy, about once or twice a week.

Doctor, what should I do? Is this a side effect of the medication, or is it related to my emotional stress? I have already decided to resign at the end of April to become my own boss, so the transition period has been quite exhausting.
I really don’t know what to do.

Kunrao Zhe, 30~39 year old female. Ask Date: 2005/04/11

Dr. Xu Weikai reply Urology


Concerned individual: Based on your description, I believe you are a responsible and dedicated employee who often places work-related stress upon yourself, leading to physical discomfort.
In fact, your erectile dysfunction may not necessarily be related to the antidepressant medication; rather, I think it coincidentally appeared at the same time.
It is true that certain antidepressants can cause delayed ejaculation, but they are more likely to prolong erection duration, and difficulties in achieving an erection are rare.
The medications you are taking generally do not have a significant impact on sexual function unless used in excessive amounts, which could affect the central nervous system and lead to drowsiness.
For some patients who are prone to premature ejaculation, we might even prescribe similar medications.
I believe that your emotional tension due to high work pressure (from starting your own business) is affecting your sexual function, and this impact can occur even without medication.
It is only when you experience high stress and then choose to take medication that you may notice issues with sexual function as your mood stabilizes.
The problems are not solely due to the medication.
If you learn to relax, both panic and sexual function issues can resolve without medication.
I recommend taking a long vacation, leaving all medications behind and not worrying about anything.
I believe that all the physical issues you are experiencing will improve.
Urology Department Chief, Hsu Wei-Kai, Response to the Taitung Hospital of the Department of Health, Executive Yuan, Concern for You.

Reply Date: 2005/04/11

More Info


Understanding post-medication sexual dysfunction can be a complex issue, especially when it involves a combination of psychological factors, medication side effects, and personal circumstances. Your experience with anxiety and the medications prescribed, such as Alprazolam (Xanax) and Paroxetine (Seroxate), is not uncommon. These medications can have various effects on sexual function, and it's important to understand the potential causes and solutions.

Firstly, it's essential to recognize that both Alprazolam and Paroxetine can influence sexual function. Alprazolam, a benzodiazepine, is often prescribed for anxiety and panic disorders. While it can help alleviate anxiety symptoms, it may also lead to sexual side effects, including decreased libido and erectile dysfunction. Paroxetine, an SSRI (selective serotonin reuptake inhibitor), is known to cause sexual side effects in many patients, including delayed ejaculation and reduced sexual desire. The initial delay in ejaculation you experienced may have been a side effect of the medication, which can sometimes improve over time as your body adjusts.

After discontinuing these medications, it's not unusual to experience a period of adjustment where sexual function may fluctuate. The fact that you can achieve an erection during masturbation but struggle during intercourse with your wife suggests that psychological factors, such as anxiety or performance pressure, may be at play. This is a common phenomenon known as "performance anxiety," where the fear of not being able to perform can lead to difficulties in sexual situations.

Your observation of reduced morning erections is also noteworthy. Morning erections, or nocturnal penile tumescence, are a sign of healthy erectile function and can be influenced by hormonal levels, psychological state, and overall health. The decrease in these occurrences may indicate that your body is still adjusting after stopping the medications, or it could be related to the stress and pressure you are currently experiencing at work.

Given your situation, here are some recommendations to consider:
1. Consult a Specialist: Since you've already seen endocrinologists and urologists, it may be beneficial to consult a sexual health specialist or a therapist who specializes in sexual dysfunction. They can provide tailored advice and support.

2. Manage Stress: Since you mentioned significant work-related stress, finding effective stress management techniques is crucial. This could include mindfulness practices, yoga, or even regular exercise, which can help alleviate anxiety and improve overall well-being.

3. Open Communication with Your Partner: Discussing your feelings and experiences with your wife can help reduce performance pressure. Open communication can foster intimacy and understanding, which may alleviate some of the anxiety associated with sexual performance.

4. Consider Therapy: Cognitive-behavioral therapy (CBT) can be effective for addressing anxiety and performance issues. A therapist can help you develop strategies to cope with anxiety and improve your sexual confidence.

5. Lifestyle Changes: Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and adequate sleep, can positively impact your sexual health. Avoiding alcohol and recreational drugs, which can exacerbate anxiety and sexual dysfunction, is also advisable.

6. Gradual Reintroduction of Sexual Activity: If you feel comfortable, gradually reintroducing sexual activity without the pressure of performance can help. This could involve focusing on intimacy and connection rather than solely on intercourse.

7. Monitor Medication Effects: If you are prescribed new medications, keep track of any side effects you experience. Discuss these with your doctor to find alternatives if necessary.

In conclusion, your experience with post-medication sexual dysfunction is multifaceted, involving both physiological and psychological elements. By addressing stress, maintaining open communication with your partner, and seeking professional guidance, you can work towards regaining your sexual confidence and function. Remember, recovery takes time, and it's essential to be patient with yourself as you navigate this process.

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