Are there any side effects of coughing?
Could you please tell me if any of the following medications that my mother has been taking for hypertension—Norvasc, ZesTRIL, or Natrilix SR—can cause a cough? Thank you.
Ms. Chen, 20~29 year old female. Ask Date: 2005/05/19
Dr. Zhang Jinteng reply Pharmacology
Hello, in response to your question: The medication Zestril, which is an ACE inhibitor for your mother's hypertension, has a side effect of causing cough.
You can inform the doctor about your mother's situation, and the doctor may switch her to another medication with fewer cough-related side effects.
Wishing you good health.
Reply Date: 2005/05/19
More Info
Blood pressure medications can indeed cause coughing as a side effect, but the likelihood and mechanism depend on the specific class of medication being used. In your mother's case, she is taking Norvasc (Amlodipine), ZesTRIL (Lisinopril), and Natrilix SR (Indapamide). Let's break down the potential for coughing associated with these medications.
1. Norvasc (Amlodipine): This medication belongs to the class of calcium channel blockers. Generally, Amlodipine is not associated with causing a cough. Its primary side effects include swelling (edema), flushing, and palpitations, but coughing is not a common issue with this drug.
2. ZesTRIL (Lisinopril): This medication is an ACE inhibitor, which is well-known for potentially causing a dry cough in some patients. The cough occurs in approximately 20% of patients taking ACE inhibitors. The mechanism behind this is related to the accumulation of bradykinin, a peptide that can cause inflammation and irritation in the respiratory tract. If your mother is experiencing a persistent cough, it is likely due to Lisinopril.
3. Natrilix SR (Indapamide): This medication is a thiazide-like diuretic. Diuretics are not typically associated with cough as a side effect. They primarily work by helping the body eliminate excess fluid and sodium, which can help lower blood pressure. Common side effects include electrolyte imbalances, dehydration, and increased urination, but coughing is not a recognized side effect.
Given this information, if your mother is experiencing a cough, it is most likely related to her use of ZesTRIL (Lisinopril). If the cough is bothersome, it would be advisable for her to consult her healthcare provider. The doctor may consider switching her to an alternative class of medication, such as an Angiotensin II receptor blocker (ARB), which does not typically cause cough. Examples of ARBs include Losartan and Valsartan.
In summary, while Norvasc and Natrilix SR are unlikely to cause coughing, ZesTRIL (Lisinopril) is a common culprit. It is essential for your mother to discuss her symptoms with her healthcare provider, who can evaluate her situation and make appropriate adjustments to her medication regimen. Managing blood pressure effectively while minimizing side effects is crucial for her overall health and well-being.
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