Abnormal Liver Function: A College Student's Guide - Internal Medicine

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"Health report shows abnormal liver function. Please help me, doctor!"


I am a college student this year! Our school conducted a health check for us freshmen! After waiting for two months, the report came out! It indicated that I have abnormal liver function with GPT (alanine aminotransferase) at 168 and GOT (aspartate aminotransferase) at 99! Both of these values exceed the normal range of 40! I am really scared now! After reading many reports about the liver, I have started to take this issue seriously! The report states that I do not have hepatitis B and recommends that I get vaccinated! Is it because my liver enzyme levels are high that the likelihood of getting hepatitis B is increased, which is why I need the vaccine? The school also asked me to undergo a follow-up test, but it takes too long—I have to wait 10 days! Will this delay affect my liver treatment? Additionally, if I change my habits and stop staying up late, will my GPT and GOT levels decrease? Also, will exercising and sweating help my condition? What foods should I eat to improve my situation?

Hao danxin de ren!, 20~29 year old female. Ask Date: 2005/11/19

Dr. Xiao Jingqin reply Internal Medicine


According to the examination, you have hepatitis.
Common causes of hepatitis include viral hepatitis, drug-induced hepatitis, autoimmune hepatitis, and fatty liver, which can lead to liver function abnormalities.
The first step is to rule out viral hepatitis, specifically acute hepatitis A and C, in addition to hepatitis B.
The hepatitis B vaccine can be administered at the gastroenterology and hepatology outpatient clinic.
Hepatitis B and C are transmitted through blood and bodily fluids, and their transmission is not related to liver enzyme levels.
Acute hepatitis A is transmitted via the fecal-oral route.
For individuals with liver function abnormalities, it is essential to stop any unnecessary medications and supplements, including herbal remedies, and to consult a gastroenterologist or hepatologist.
Maintaining a normal routine is important; if there is no jaundice present in hepatitis, there is no immediate life-threatening danger.
It is advisable to seek a hepatologist for blood tests and, if necessary, an abdominal ultrasound, as this is currently the most important course of action.

Reply Date: 2005/11/19

More Info


Understanding abnormal liver function can be quite daunting, especially for a college student who may not have had much exposure to medical terminology or health issues. Based on your recent health check-up, your liver function tests (LFTs) show elevated levels of GPT (ALT) at 168 and GOT (AST) at 99, both of which are significantly above the normal reference range (typically around 10-40 for both enzymes). This indicates that there is some degree of liver inflammation or damage, which is a cause for concern.

Firstly, it’s important to understand what these liver enzymes indicate. ALT (GPT) is primarily found in the liver, and its elevation is often associated with liver cell injury. AST (GOT) is found in various tissues, including the liver, heart, and muscles, so while it can indicate liver issues, it is not as specific as ALT. The fact that both enzymes are elevated suggests that there is a liver-related issue that needs to be addressed.

You mentioned that you have been tested for Hepatitis B and that the results were negative. This is a positive aspect, as viral hepatitis is a common cause of elevated liver enzymes. However, it’s crucial to rule out other potential causes of liver dysfunction, such as Hepatitis C, alcohol use, fatty liver disease, or even medication-induced liver injury. Your healthcare provider may recommend further testing to explore these possibilities.

Regarding the recommendation for the Hepatitis B vaccine, it is generally advised for individuals who are at risk of exposure to the virus, even if they currently test negative. The vaccine can provide protection against future infections, which is particularly important given your elevated liver enzymes.

As for the waiting period for your follow-up tests, while it may feel concerning, a short delay in retesting typically does not significantly impact your liver health, especially if you are not experiencing any acute symptoms like jaundice (yellowing of the skin and eyes), severe fatigue, or abdominal pain. However, it is essential to avoid any substances that could further stress your liver during this time, such as alcohol, recreational drugs, and unnecessary medications or supplements.

You asked about lifestyle changes, such as reducing late-night activities and exercising. Improving your sleep hygiene and ensuring you get adequate rest can positively impact your overall health, including liver function. Chronic sleep deprivation can lead to metabolic disturbances and may exacerbate liver issues. Regular exercise is also beneficial; it can help reduce liver fat, improve metabolic health, and enhance overall well-being. Aim for at least 150 minutes of moderate aerobic activity per week, along with strength training exercises.

Dietary choices play a crucial role in liver health as well. Focus on a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Foods high in antioxidants, such as berries and leafy greens, can help combat oxidative stress in the liver. Additionally, reducing your intake of saturated fats, refined sugars, and processed foods can help manage liver health. Staying hydrated is also essential, so drink plenty of water throughout the day.

In summary, while your elevated liver enzymes are concerning, there are steps you can take to manage your health effectively. Follow up with your healthcare provider for further testing and guidance, maintain a healthy lifestyle, and consider vaccination against Hepatitis B. Remember, early intervention and lifestyle modifications can significantly improve liver health and overall well-being.

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