Does Forteo Help Improve Osteoporosis in Elderly Patients?

Regarding bone growth stimulators?

Hello, doctor.
I have an elderly family member who is nearly 80 years old and has been suffering from osteoporosis for a long time.
I would like to know if the use of a bone anabolic agent, "Forteo," would significantly benefit their condition.
Thank you.

Ms. Zhang, 40~49 year old female. Ask Date: 2006/08/09

Dr. Ye Qingnian reply Orthopedics

FORTEO is a new medication for osteoporosis that has shown better efficacy compared to current treatments, although it is more expensive.
It is effective for osteoporosis, but patients still need to supplement with calcium and engage in daily walks in the morning or evening to get some sunlight, which helps the skin produce vitamin D, as well as to exercise (such as walking).

Reply Date: 2006/08/09

More Info

Forteo (teriparatide) is a medication specifically designed to treat osteoporosis, particularly in patients who are at high risk for fractures. It is a recombinant form of parathyroid hormone that stimulates bone formation, making it a unique option compared to other osteoporosis treatments that primarily focus on inhibiting bone resorption. For elderly patients, especially those around 80 years of age with a long history of osteoporosis, Forteo can indeed provide significant benefits.

Clinical studies have demonstrated that Forteo can increase bone mineral density (BMD) and reduce the risk of vertebral and non-vertebral fractures in postmenopausal women and men with osteoporosis. The mechanism of action involves stimulating osteoblasts, the cells responsible for bone formation, which leads to an increase in bone mass and strength. This is particularly important for elderly patients, as they are at a higher risk for fractures due to decreased bone density and strength.

In terms of administration, Forteo is typically given as a daily subcutaneous injection. The treatment duration is generally recommended for up to 24 months, after which patients may transition to other osteoporosis therapies to maintain the benefits achieved during the Forteo treatment. It is important to note that while Forteo is effective, it is also relatively expensive compared to other osteoporosis medications, which may be a consideration for some patients and their families.

For elderly patients, particularly those with a history of fractures or very low BMD (T-score less than -2.5), Forteo can be a critical part of a comprehensive osteoporosis management plan. However, it is essential to combine this treatment with lifestyle modifications, such as adequate calcium and vitamin D intake, weight-bearing exercises, and fall prevention strategies, to maximize the benefits and reduce the risk of fractures.

Moreover, it is crucial to monitor the patient's overall health and any potential side effects associated with Forteo, such as dizziness or leg cramps. Regular follow-ups with healthcare providers to assess bone density and fracture risk are also recommended.

In summary, Forteo can significantly help improve osteoporosis in elderly patients, particularly those at high risk for fractures. It is essential to consider individual patient factors, including their overall health, fracture history, and ability to adhere to a treatment regimen, when determining the appropriateness of Forteo as a treatment option. Always consult with a healthcare provider to tailor the treatment plan to the specific needs of the patient.

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