Finasteride: Risks and Benefits for Hair Loss Treatment - Dermatology

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Could you please provide more context or specify what you mean by "柔沛"?


I saw on the Department of Health's website that Finasteride is a competitive and selective inhibitor of Steroid Type II 5α-reductase.
Its pharmacological action demonstrates that Finasteride inhibits Steroid Type II 5α-reductase, thereby blocking the formation of 5α-dihydrotestosterone (DHT), which helps prevent hair loss.

I would like to know if taking Finasteride could lead to side effects similar to those experienced by patients on steroids, such as moon facies or buffalo hump.
A friend of mine who is in medical school mentioned that steroid medications are lipophilic and can accumulate in cells, potentially affecting metabolism, which makes me quite anxious.
I don’t want to jeopardize my health for the sake of my hair.
I have been taking it for a whole year now and have not noticed any side effects.
I would appreciate your help in addressing my concerns.
Thank you.

A Kai, 20~29 year old female. Ask Date: 2009/10/26

Dr. Huang Ruiyun reply Dermatology


Hello: There is a significant misunderstanding here.
Steroids actually refer to a large class of compounds that can come from animals, plants, fungi, and can also be synthetically produced.
When we commonly refer to steroids, we are usually only talking about "glucocorticoids," while another well-known class of steroids is "anabolic steroids," which are banned substances for athletes.
If one mistakenly believes that all steroids are the same and takes glucocorticoids, which are used to treat lupus erythematosus, thinking they will become strong like athletes, that would be quite a joke.
Ropivacaine does not belong to the aforementioned class of steroids; in fact, it does not have any steroid-like effects.
Its true role is as a "reduction & competitive inhibitor," without the side effects you described.
Wishing you peace and health.

Reply Date: 2009/10/26

More Info


Finasteride is a medication primarily used to treat male pattern baldness (androgenetic alopecia) by inhibiting the action of the enzyme 5-alpha reductase type II. This enzyme is responsible for converting testosterone into dihydrotestosterone (DHT), a hormone that plays a significant role in hair loss. By reducing DHT levels, Finasteride can help slow hair loss and promote regrowth in some men. However, as with any medication, it is essential to understand both the benefits and potential risks associated with its use.


Benefits of Finasteride
1. Effective Hair Loss Treatment: Clinical studies have shown that Finasteride can be effective in preventing further hair loss and promoting regrowth in men with androgenetic alopecia. Many users report noticeable improvements in hair density and thickness after consistent use over several months.

2. Convenient Administration: Finasteride is taken orally, usually in a 1mg dose for hair loss treatment, making it easy to incorporate into a daily routine.

3. Long-Term Results: For many men, the benefits of Finasteride can be sustained as long as the medication is taken consistently. If treatment is stopped, however, any regrown hair may be lost within a year.


Risks and Side Effects
While Finasteride is generally well-tolerated, it does come with a range of potential side effects, some of which can be concerning:
1. Sexual Side Effects: The most commonly reported side effects include decreased libido, erectile dysfunction, and ejaculation disorders. These side effects can occur in a small percentage of users and may persist even after discontinuation of the medication.

2. Gynecomastia: Some men may experience breast tenderness or enlargement (gynecomastia) while taking Finasteride. This side effect is not common but can be distressing for those affected.

3. Mood Changes: There have been reports of mood alterations, including depression and anxiety, in some users. While the causal relationship is not fully understood, it is essential to monitor any psychological changes while on the medication.

4. Potential for Hormonal Imbalance: Since Finasteride alters hormone levels by reducing DHT, there is concern about its long-term effects on hormonal balance. However, it does not have the same profile as anabolic steroids, which can lead to more severe side effects like "moon face" or "buffalo hump." Finasteride is not a steroid; it does not promote muscle growth or fat redistribution in the same way.


Comparison with Steroids
Your concern about Finasteride having similar side effects to those associated with steroid use is understandable, especially given the hormonal nature of both types of medications. However, it is crucial to differentiate between them:
- Steroids: Anabolic steroids can lead to significant metabolic changes, including weight gain, changes in fat distribution, and various psychological effects. They are often used for muscle building and performance enhancement, which can lead to a range of health issues.

- Finasteride: As a selective 5-alpha reductase inhibitor, Finasteride primarily targets DHT without the broader metabolic effects associated with anabolic steroids. While it can cause sexual side effects and hormonal changes, it does not typically lead to the same physical changes seen with steroid use.


Conclusion
If you have been taking Finasteride for a year without noticeable side effects, it is a positive sign. However, it is essential to remain vigilant and communicate with your healthcare provider about any changes in your health or well-being. Regular check-ins can help ensure that the benefits of the medication continue to outweigh any potential risks. If you have concerns about long-term use or specific side effects, discussing alternative treatments or adjunct therapies with a dermatologist or healthcare professional may also be beneficial.

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