Biochemical Reports: Managing Diabetes and Kidney Health - Internal Medicine

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Family's biochemical report


Hello Dr.
Wu, I consulted with you in February this year, and today I am attaching more biochemical report data for your explanation.
My father is 60 years old today and has been suffering from diabetes and kidney stones for a long time.
He was originally seeing a family medicine doctor, but for some reason, his case was transferred to nephrology.
I have attached the examination reports from February of this year to the present and would like to ask you if there are any signals in the reports due to diabetes that may indicate other complications.
Thank you very much, and I wish you peace.

Diabetes history: 7-8 years
Kidney stones: underwent surgery 2 years ago
Occasional gout symptoms
I would like to purchase Abbott nutritional products (Glucerna or Nepro) for my father.
Based on the report data, which product should be used? Does he need to restrict protein intake due to his condition?
Here are the lab results:
- HbA1c:
- February: 7.8% (4.0 - 6.0)
- April: 8.7% (4.0 - 6.0)
- June: 8.2% (4.0 - 6.0)
- February: 7.7% (4.0 - 6.0)
- SGOT (AST):
- February: 40 IU/L (5-34)
- April: 33 IU/L (5-34)
- May: 62 IU/L (5-34)
- August: 49 IU/L (5-34)
- SGPT (ALT):
- February: 74 IU/L (0-40)
- April: 49 IU/L (0-40)
- May: 81 IU/L (0-40)
- August: 61 IU/L (0-40)
- Uric Acid:
- February: 4.2 mg/dL (Male: 2.5-7.5, Female: 1.9-6.5)
- April: 5.8 mg/dL (Male: 2.5-7.5, Female: 1.9-6.5)
- Total Cholesterol:
- February: 219 mg/dL (130-200)
- April: 199 mg/dL (130-200)
- August: 220 mg/dL (130-200)
- Triglycerides:
- February: 423 mg/dL (Male: 50-200, Female: 35-165)
- April: 370 mg/dL (Male: 50-200, Female: 35-165)
- August: 438 mg/dL (Male: 50-200, Female: 35-165)
- Glucose A.C.
(Fasting Blood Sugar):
- February: 106 mg/dL (Biochemical instrument: 70-110, Glucometer: <100)
- April: 151 mg/dL (Biochemical instrument: 70-110, Glucometer: <100)
- May: 130 mg/dL (Biochemical instrument: 70-110, Glucometer: <100)
- April (Postprandial): 216 mg/dL (Biochemical instrument: 90-130, Glucometer: <140)
- June (Postprandial): 182 mg/dL (Biochemical instrument: 90-130, Glucometer: <140)
- HDL Cholesterol:
- February: 36.6 mg/dL (Male: 29-71, Female: 35-85)
- April: 35.4 mg/dL (Male: 29-71, Female: 35-85)
- August: 33.7 mg/dL (Male: 29-71, Female: 35-85)
- LDL Cholesterol:
- April: 103.1 mg/dL (0-130)
- August: 119.0 mg/dL (0-130)
- April (Calculated): 89.6 mg/dL (0-130)
- CHOL/HDL-C Ratio:
- February: 5.98 (<5)
- April: 5.62 (<5)
- August: 6.53 (<5)
- Urine Creatinine:
- April: 87.38 mg/dL
- August: 119.66 mg/dL
- Micro Albumin:
- April: 4.0 mg/dL (Random Urine <1.9 mg/dL)
- August: 2.4 mg/dL (Random Urine <1.9 mg/dL)
- ACR:
- April: 45.78 µg/mg Creatinine (<30)
- August: 20.06 µg/mg Creatinine (<30)
- GFR:
- April 6: 56 mL/min/1.73m² (>90)
- April 18: 52 mL/min/1.73m² (>90)
- April 24: 64 mL/min/1.73m² (>90)
- May 22: 61 mL/min/1.73m² (>90)
- June 13: 64 mL/min/1.73m² (>90)
- August 7: 60 mL/min/1.73m² (>90)
- Creatinine:
- April 6: 1.31 mg/dL (0.5-1.3)
- April 18: 1.4 mg/dL (0.5-1.3)
- April 24: 1.16 mg/dL (0.5-1.3)
- May 22: 1.22 mg/dL (0.5-1.3)
- June 13: 1.16 mg/dL (0.5-1.3)
- August 7: 1.23 mg/dL (0.5-1.3)
- PSA (EIA):
- April 25: 0.98 ng/mL (<4.00)

MAMA, 60~69 year old female. Ask Date: 2012/08/23

Dr. Wu Jiyu reply Internal Medicine


My father is 60 years old today and has long been troubled by diabetes and kidney stones.
He has been seeing a family medicine doctor, but for some reason, his case has been referred to a nephrologist.
I have attached the examination reports from February of this year to the present and would like to ask the physician if diabetes can lead to other complications.
Are there any signals in the reports that we should be aware of? Thank you, and I wish you peace.
Diabetes history: 7-8 years
Kidney stones: Surgery 2 years ago
Occasional gout symptoms.
1.
Can diabetes lead to other complications? Based on the ACR of 20.06 ug/mg from August 101, it seems not yet indicative of diabetic nephropathy.
However, considering your father's age of 60, the GFR of 60 mL/min/1.73m² from August 7, 101 is low (normal for this age should be around 80 mL/min/1.73m²).
Therefore, we can discuss the risk factors:
1.
Hypertension: Since no data was provided, it is recommended to monitor blood pressure regularly, aiming for an ideal reading of <130/80 mmHg.

2.
Hyperglycemia: HbA1c: 7.7%-8.7%.
It is advisable to control this through medication, diet, and exercise, with an ideal HbA1c <7.0%.

3.
Hyperlipidemia: LDL cholesterol: 119.0 mg/dl from August 101.
Although this is below 130 mg/dl, it would be better if it could be reduced to below 100 mg/dl.

4.
Kidney stones: Regular follow-up is recommended.

5.
Gout: Uric Acid: 5.8 mg/dl from April 101.
Dietary control is sufficient.
Other:
1.
I would like to purchase Abbott nutritional products (Glucerna or Nepro) for my father.
Based on the report data, which one should be used? Since A1C > 7.0% and ACR < 30 mg/g, it is recommended to prioritize blood sugar control (i.e., Glucerna).
As for a low-protein diet, further discussion with a nutritionist is advisable.

2.
The liver function index is elevated.
If it is not caused by lipid-lowering medication, further monitoring is recommended.
Thank you for your concern from the nephrology department of Changhua Hospital, and thank you for your inquiry.

Reply Date: 2012/08/23

More Info


Understanding the biochemical reports related to diabetes and kidney health is crucial, especially for individuals with a history of diabetes and related complications. In your father's case, the reports indicate several important factors that need to be addressed.

1. Diabetes Management: Your father's HbA1c levels have been consistently above the normal range (4.0 - 6.0%), with values ranging from 7.7% to 8.7%. This indicates that his blood sugar levels have not been well controlled over the past few months. Ideally, for individuals with diabetes, the target HbA1c should be below 7.0% to minimize the risk of complications. Poorly controlled diabetes can lead to various complications, including diabetic nephropathy, which is a significant concern given his history of kidney stones and current kidney function.

2. Kidney Function: The Glomerular Filtration Rate (GFR) values reported (around 60 mL/min) suggest that your father's kidney function is declining, as normal GFR is typically above 90 mL/min for his age. A GFR below 60 mL/min can indicate chronic kidney disease (CKD). Additionally, the presence of microalbumin in the urine (4.0 mg/dL) and an Albumin-to-Creatinine Ratio (ACR) of 20.06 µg/mg (which is above the normal threshold of <30 µg/mg) suggests that there is some degree of kidney damage, likely related to his diabetes.

3. Liver Function: The elevated liver enzymes (SGOT and SGPT) indicate that there may be some liver stress or damage. This could be due to various factors, including medications, alcohol consumption, or fatty liver disease, which is common in individuals with diabetes. Monitoring liver function is essential, especially if he is on medications for diabetes management.

4. Uric Acid and Gout: The uric acid levels have shown an increase (from 4.2 mg/dL to 5.8 mg/dL), which could indicate a risk for gout, especially since he has experienced symptoms related to gout. Dietary modifications and possibly medications may be necessary to manage uric acid levels.

5. Nutritional Considerations: Regarding nutritional supplements, it is essential to prioritize blood sugar control first. Given the HbA1c levels, it would be advisable to focus on managing blood glucose levels through diet, exercise, and possibly medication before considering nutritional supplements like those from Abbott (e.g., Glucerna for diabetes management). A consultation with a dietitian specializing in diabetes management would be beneficial to tailor a diet plan that considers both diabetes and kidney health.

6. Protein Intake: As for protein intake, if kidney function continues to decline, a low-protein diet may be recommended to reduce the workload on the kidneys. However, this should be discussed with a healthcare provider who can assess the overall health status and kidney function before making dietary restrictions.

7. Follow-Up and Monitoring: It is crucial for your father to have regular follow-ups with his healthcare provider, including nephrologists and endocrinologists, to monitor his diabetes and kidney function closely. Regular blood tests, urine tests, and possibly imaging studies may be necessary to track any changes in his condition.

In summary, your father's biochemical reports indicate that he is at risk for complications related to diabetes and kidney health. It is essential to focus on controlling blood sugar levels, monitoring kidney function, and addressing any liver issues while considering dietary modifications. Regular follow-ups with healthcare providers will be vital in managing his overall health effectively.

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