Side Effects of Bone Strengthening Injections: Should You Continue?

What are the side effects of receiving a bone-strengthening injection?

Hello, doctor: I received a bone-strengthening injection last year, but I didn't notice any improvement.
Instead, I've been experiencing frequent bone pain, lower back pain, nausea, and headaches, and I feel weaker overall.
Should I still consider getting the bone-strengthening injection this year?

Niming, 50~59 year old female. Ask Date: 2013/05/19

Dr. Chen Xingyuan reply Orthopedics

Dear Online Friends,
Every medication has its indications and side effects.
The Bone Strength injection is primarily used for the treatment of osteoporosis, aimed at reducing bone loss and consequently lowering the incidence of fractures.
Acute phase reactions following Bone Strength infusion may include symptoms such as fever (18%), muscle pain (9%), flu-like symptoms (8%), headache (7%), joint pain (7%), atrial fibrillation, and hypertension, which typically resolve within about three days.
It is not recommended for individuals with impaired kidney function.
More serious side effects include osteonecrosis of the jaw and atypical fractures, both occurring at a rate of less than 1%.

Commonly reported symptoms such as bone pain, lower back pain, nausea, headache, and increased fatigue are generally not related to the Bone Strength injection.
If you feel unwell after the Bone Strength injection, there are other medications available for the treatment of osteoporosis, but it is essential to consult your physician for a careful evaluation.
Attached is an educational pamphlet on the treatment of osteoporosis for your reference.

Wishing you health and safety!
Sincerely,
Dr.
Chen

Reply Date: 2013/05/19

More Info

When considering whether to continue with bone-strengthening injections, such as those for osteoporosis, it is crucial to evaluate both the effectiveness of the treatment and any side effects experienced. In your case, it appears that after receiving the injection last year, you have not only failed to see improvement but have also experienced a range of adverse effects, including bone pain, back pain, nausea, headaches, and a general feeling of weakness.

Bone-strengthening injections, like those containing teriparatide (Forteo) or denosumab (Prolia), are designed to help increase bone density and reduce the risk of fractures in individuals with osteoporosis. However, as with any medication, they can come with side effects. Common side effects associated with these treatments may include mild reactions such as injection site pain, nausea, and headaches. More serious side effects, although rare, can include osteonecrosis of the jaw and atypical femoral fractures.

The symptoms you are experiencing—persistent bone pain, back pain, nausea, and headaches—are concerning and warrant a thorough evaluation. It is essential to differentiate whether these symptoms are directly related to the injection or if they stem from other underlying conditions. For instance, if you have pre-existing conditions such as arthritis or other musculoskeletal disorders, these could contribute to your discomfort and may not be related to the injection itself.

Given your situation, it is advisable to consult with your healthcare provider before proceeding with another injection. Your doctor can conduct a comprehensive assessment, which may include imaging studies or blood tests, to determine the cause of your symptoms and whether they are indeed linked to the previous treatment. They may also consider alternative treatments for osteoporosis that could be more suitable for you, especially if the current regimen has not been effective.

In addition to medication, lifestyle modifications can play a significant role in managing osteoporosis. Engaging in weight-bearing exercises, ensuring adequate calcium and vitamin D intake, and avoiding smoking and excessive alcohol consumption can all contribute to better bone health. Your healthcare provider may also refer you to a physical therapist who can help design a tailored exercise program to strengthen your bones and improve your overall physical condition.

In conclusion, while bone-strengthening injections can be beneficial for many individuals with osteoporosis, your experience of adverse effects and lack of improvement suggests that it may be time to reevaluate your treatment plan. Open communication with your healthcare provider is key to finding a safe and effective approach to managing your bone health. They can help you weigh the risks and benefits of continuing with the same treatment versus exploring alternative options that may better suit your needs.

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