Unexpected Bleeding After Months on Diane-35: Causes and Solutions - Obstetrics and Gynecology

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Unexpected bleeding occurred after several months of taking Diane-35?


Hello Dr.
Lu, I started using Diane-35 for contraception in November of last year, and I have not experienced any significant discomfort or other side effects.
I have only noticed a decrease in menstrual flow and a shorter duration of my periods.
However, in the last two cycles, I began to experience bleeding similar to menstruation when I had about 7 to 10 pills left in the pack.
The amount of bleeding is less than a typical period, but it is also not as light as ovulation spotting; it is an intermediate amount, and the color is a darker shade of red similar to menstrual blood.
I am still continuing to take Diane-35, and I would like to ask the doctor: what could be the possible reasons for this situation? If the dosage of this medication is not suitable for my condition, do you have any other recommendations? Thank you!

Angela, 30~39 year old female. Ask Date: 2015/08/05

Dr. Lü Lizheng reply Obstetrics and Gynecology


In general, previous experiences with medication have been fine, but this time there has been mild menstrual irregularity.
There could be many possible reasons for this, such as insufficient sleep, stress, or the influence of traditional Chinese medicine supplements.
It may be advisable to observe for another month or two before deciding whether to change the medication.
Sincerely, Dr.
Li-Cheng Lu, Taoyuan Hospital.

Reply Date: 2015/08/05

More Info


Unexpected bleeding while on hormonal contraceptives like Diane-35 can be concerning, especially when it deviates from your usual menstrual pattern. Diane-35 is a combined oral contraceptive pill that contains cyproterone acetate and ethinyl estradiol. It is commonly prescribed not only for contraception but also for managing conditions like acne and hirsutism due to its anti-androgenic properties.

There are several potential reasons for the unexpected bleeding you are experiencing:
1. Hormonal Fluctuations: When you start taking a new contraceptive, your body may take some time to adjust to the hormonal changes. This adjustment period can lead to breakthrough bleeding, especially during the first few months of use. The bleeding you describe, which occurs towards the end of your pill pack, could be a sign that your body is still adapting to the medication.

2. Missed Doses or Inconsistent Use: If there have been any missed doses or if the pills were taken at irregular times, this can lead to hormonal imbalances that may cause unexpected bleeding. It's crucial to take the pill consistently at the same time every day to maintain stable hormone levels.

3. Stress and Lifestyle Factors: External factors such as stress, significant changes in weight, or alterations in your daily routine can impact your menstrual cycle. Stress, in particular, can affect hormone levels and lead to irregular bleeding.

4. Underlying Health Issues: Conditions such as polycystic ovary syndrome (PCOS), uterine fibroids, or other hormonal imbalances may also contribute to irregular bleeding. If the bleeding persists or worsens, it may be worth discussing these possibilities with your healthcare provider.

5. Medication Interactions: If you are taking other medications or supplements, they may interact with Diane-35 and affect its efficacy or your hormonal balance, leading to unexpected bleeding.

Given that you have been on Diane-35 for several months without significant issues, it may be advisable to monitor the situation for another one to two cycles. If the bleeding continues or if you experience other concerning symptoms (such as severe pain, heavy bleeding, or signs of infection), it would be prudent to consult your healthcare provider for further evaluation.

As for alternatives, if you find that Diane-35 is not suitable for you due to the breakthrough bleeding or if you have concerns about the dosage, there are several options available:
1. Different Formulations: There are various formulations of combined oral contraceptives with different hormone dosages and types. A lower-dose pill may be more appropriate for you, especially if you are experiencing side effects.

2. Non-Hormonal Options: If hormonal contraceptives are not suitable, non-hormonal methods such as copper IUDs or barrier methods (like condoms) can be considered. These methods do not involve hormones and may be preferable for some individuals.

3. Alternative Hormonal Methods: Other hormonal contraceptive methods, such as the contraceptive patch, vaginal ring, or hormonal IUDs, may provide effective contraception with different side effect profiles.

In conclusion, while unexpected bleeding can be a common side effect of starting a new contraceptive, it is essential to keep track of your symptoms and consult with your healthcare provider if they persist. They can help determine the underlying cause and suggest the most appropriate contraceptive method for your needs. Always prioritize open communication with your healthcare provider regarding any concerns or changes in your health while on medication.

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