Can You Rule Out Herpes After Negative HSV Tests? - Urology

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Herpes or general injury infection


Hello Doctor: I inquired last Saturday about issues related to a foreskin injury and herpes.
At that time, I mentioned that two weeks after inappropriate sexual activity, both HSV 1 and 2 IgG tests were negative.
Later, due to concerns that an initial infection might not be detectable, I was advised by others to retest for HSV 1 and 2 IgM, which also returned negative.
Can I rule out herpes with these results? Thank you for your patient response.

Kunrao, 30~39 year old female. Ask Date: 2015/12/16

Dr. Xu Weikai reply Urology


Concern: Hello, basically, herpes is something that almost everyone around has been exposed to or has been infected with at some point.
In clinical practice, this condition does not require special treatment and can heal on its own.
Therefore, in my outpatient clinic, we generally do not provide treatment specifically for herpes; we only focus on controlling bacterial infections related to the skin when herpes blisters break.
If there are any unclear points, feel free to ask again, and we can discuss and research further.
Answers found online should only be used as a reference; if necessary, it is still important to seek medical attention at a healthcare facility.
Ministry of Health and Welfare, Taitung Hospital, cares about you.
This response is provided by Dr.
Hsu Wei-Kai, Director of the Urology Department at our hospital.

Reply Date: 2015/12/16

More Info


When it comes to herpes simplex virus (HSV) testing, understanding the implications of negative results is crucial for peace of mind and health management. Based on your situation, you have undergone testing for both HSV-1 and HSV-2 IgG and IgM antibodies, with all results returning negative. This is a positive indication, but let’s delve deeper into what these results mean and whether you can confidently rule out herpes.

Firstly, the IgG test is designed to detect antibodies that your body produces in response to a past infection with HSV. A negative IgG result generally indicates that you have not been infected with the virus, or that the infection occurred very recently, as it can take time for the body to produce detectable levels of IgG antibodies. Typically, IgG antibodies can take anywhere from 2 to 12 weeks post-exposure to become detectable. Therefore, if your test was conducted two weeks after potential exposure, it is still within the window period for IgG testing.

On the other hand, the IgM test is often used to identify recent infections. However, it is important to note that the IgM test can sometimes yield false positives and is not always reliable for diagnosing herpes. In your case, since both IgG and IgM tests returned negative, it is a strong indication that you likely do not have an active herpes infection.

However, it is essential to consider the timing of your tests. If you were tested too soon after exposure, it is possible that the virus was not yet detectable. The "window period" for HSV can vary, and while IgG tests are generally reliable after 12 weeks, IgM tests can be misleading. Therefore, if you are still concerned about potential exposure, it might be prudent to retest after a longer period, such as 12 weeks from the date of exposure.

Additionally, clinical symptoms play a significant role in diagnosing herpes. If you have not experienced any symptoms such as sores, blisters, or other signs of herpes, this further supports the likelihood that you are not infected. However, if you do develop symptoms in the future, it is important to seek medical attention and possibly undergo further testing.

In summary, based on your negative HSV-1 and HSV-2 IgG and IgM tests, it is reasonable to rule out herpes simplex virus infection at this time. However, if you have any lingering doubts or if symptoms arise, consider consulting with a healthcare provider for further evaluation and possibly retesting after the appropriate window period. It's also important to maintain open communication with any sexual partners about STI testing and safe practices to ensure mutual health and safety.

Lastly, it is understandable to feel anxious about potential infections, especially with the stigma surrounding STIs. Remember that many people carry HSV without symptoms, and it is a common virus. Seeking support from healthcare professionals can help alleviate fears and provide accurate information. Always prioritize your health and well-being, and do not hesitate to reach out for further guidance.

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