Low CCR Levels: Do You Need a Low-Protein Diet? - Internal Medicine

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Regarding the CCR (Creatinine Clearance Rate) renal function index?


Hello, doctor.
I would like to ask why my creatinine clearance (CCR) is low, even though my other test results are mostly normal.
I have had several tests, and my CCR has consistently been between the low 50s and low 60s.
As a result, I am hesitant to eat too much.
I am 53 years old and weigh 38 kg, and I am a patient with rheumatoid arthritis (RA).
Should I implement a low-protein diet? Below are my recent test results.
Thank you very much!
April test results:
Blood Creatinine: 0.86 mg/dL
Urine Creatinine: 40.2 mg/dL
Total Volume: 1640 mL
CCR: 53.2 mL/min
24-hour Urine Protein: <0.08 g
GFR: 71.07 mL/min
Last October test results:
Na: 137 mEq/L
K: 3.7 mEq/L
Ca: 9.4 mg/dL

Margot, 50~59 year old female. Ask Date: 2016/05/23

Dr. Wu Jiyu reply Internal Medicine


Hello: The 24-hour creatinine clearance rate is clinically used as an indirect indicator of glomerular filtration rate.
While its accuracy is relatively high, it can still be affected by urine collection methods, medication use, and testing errors, which may influence the results.
It is recommended that you bring a list of your current medications to a nephrology clinic for appropriate advice.

For your situation, a 24-hour creatinine clearance rate of 50-60 indicates very early-stage chronic kidney disease, during which there may not be obvious signs of kidney disease.
If managed properly, rapid deterioration of kidney function may not occur.
However, it is crucial to be particularly cautious with medications (especially pain relievers, folk remedies, or unknown drugs) that may affect kidney function during the early stages of kidney disease.
Regular monitoring of important kidney disease indicators such as blood pressure, blood glucose, lipid levels, albumin, uric acid, and proteinuria is also essential.
Regarding protein intake, it should be assessed based on your overall condition.
If you are underweight, a comprehensive nutritional evaluation should be conducted to avoid the risk of malnutrition before experiencing the benefits of a low-protein diet.
Finally, it is still advisable to visit a nephrologist for a comprehensive clinical evaluation to receive the most suitable recommendations for your situation.

Reply Date: 2016/05/23

More Info


Understanding low creatinine clearance rate (CCR) levels and whether a low-protein diet is necessary can be a complex issue, particularly for individuals with underlying health conditions such as rheumatoid arthritis (RA). Your reported CCR levels, which range from the low 50s to 60s, indicate a mild reduction in kidney function. This is consistent with early-stage chronic kidney disease (CKD), where the kidneys are still functioning but not at optimal levels.

The CCR is a measure of how well your kidneys are filtering waste from your blood. A normal CCR is typically above 90 mL/min, and values below this threshold can indicate some degree of kidney impairment. In your case, a CCR of around 53 suggests that while your kidney function is reduced, it is not severely impaired. Your GFR (glomerular filtration rate) of 71.07 also indicates that your kidney function is still relatively preserved, although it is on the lower end of normal.

Given your age, weight, and the presence of RA, it is essential to consider your overall nutritional needs. RA can lead to increased inflammation and may affect your nutritional status, which is crucial for maintaining muscle mass and overall health. Your low body weight of 38 kg raises concerns about potential malnutrition, especially if you were to adopt a low-protein diet without careful planning.

A low-protein diet is often recommended for individuals with advanced CKD to reduce the workload on the kidneys and slow the progression of kidney disease. However, in the early stages of CKD, such as in your case, the need for a low-protein diet may not be as critical. Instead, the focus should be on maintaining a balanced diet that meets your caloric and protein needs while also considering your kidney function.

Before making any dietary changes, it is crucial to consult with a nephrologist or a registered dietitian who specializes in kidney disease. They can provide personalized recommendations based on your specific health status, dietary preferences, and lifestyle. They may suggest a moderate protein intake rather than a strict low-protein diet, ensuring that you receive adequate nutrition without overburdening your kidneys.

In addition to protein intake, monitoring other dietary factors such as sodium, potassium, and phosphorus is essential, especially as kidney function declines. Since you mentioned that your urine protein levels are low (<0.08 g), this is a positive sign, indicating that your kidneys are not leaking significant amounts of protein, which can be a concern in kidney disease.

In summary, while your low CCR levels warrant attention, a low-protein diet may not be necessary at this stage. Instead, focus on a well-balanced diet that supports your overall health, and consult with healthcare professionals to tailor a dietary plan that meets your needs. Regular monitoring of your kidney function and nutritional status will be vital in managing your health as you navigate the complexities of CKD and RA.

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