Androcur for Acne: Side Effects and Alternatives Explained

Q: Androcur for Acne: Side Effects and Alternatives Explained

Dear Mr. <br>Cong：<br>1. <br>Androcur® (50mg, generic name： Cyproterone) is indicated for the treatment of prostate tumors, severe hypersexuality, significant masculinization symptoms, hirsutism, acne, and more. <br>Potential side effects may include nausea, vomiting, abdominal p

Treatment for acne includes taking Androcur?

To treat acne, I underwent blood tests that showed elevated testosterone levels and have been taking Androcur for several months.
However, my libido has significantly decreased.
Previously, I would wake up with an erection every morning, but now that doesn't happen.
I am curious why the doctor prescribed this medication.
I found online that it is typically given to individuals transitioning to female, and even the pharmacist was surprised when I picked up the prescription.
Currently, I am experiencing significant side effects: my underarm hair is rapidly diminishing, my facial hair growth is very slow, I have gained weight, and I have recently started feeling nauseous with a loss of appetite.
Additionally, the volume of my sperm has noticeably decreased.
Should I continue taking this medication? Could it lead to infertility? Are there no alternative medications available?

Cong, 30~39 year old female. Ask Date: 2016/06/25

Dr. Xiao Yongxun reply Internal Medicine

Dear Mr.
Cong:
1.
Androcur® (50mg, generic name: Cyproterone) is indicated for the treatment of prostate tumors, severe hypersexuality, significant masculinization symptoms, hirsutism, acne, and more.
Potential side effects may include nausea, vomiting, abdominal pain, slight weight gain, depression, and reproductive function suppression.
Therefore, your concerns are understandable.
2.
The treatment of acne often involves the use of topical antibiotics or anti-acne medications, and sometimes oral antibiotics or retinoids may be prescribed.
Physicians may also consider the use of anti-androgens (which you are currently using), spironolactone, and anti-inflammatory medications depending on the situation.
3.
It is advisable for you to further discuss this with your dermatologist.

Reply Date: 2016/06/25

More Info

Androcur, known generically as cyproterone acetate, is a medication primarily used to treat conditions related to excessive androgen levels, such as severe acne, hirsutism (excessive hair growth), and certain types of prostate cancer. It works as an anti-androgen by blocking the effects of testosterone and reducing its production, which can be beneficial for individuals with high testosterone levels, particularly in cases of acne.

In your situation, it seems that your doctor prescribed Androcur due to elevated testosterone levels, which can contribute to acne and other androgen-related symptoms. While it is true that Androcur is sometimes used in transgender hormone therapy to suppress male characteristics, it is also a legitimate treatment for women and men with conditions caused by high androgen levels.

However, as you've noted, Androcur can have significant side effects, particularly when used over an extended period. Common side effects include decreased libido, weight gain, nausea, and changes in hair growth patterns, which you are experiencing. The reduction in sexual desire and changes in body hair can be concerning, especially since these effects can significantly impact your quality of life.

Regarding your concerns about infertility, while Androcur can affect sperm production and testosterone levels, it is not typically associated with permanent infertility. However, if you are considering starting a family in the future, it is essential to discuss this with your healthcare provider. They may recommend monitoring your hormone levels or considering alternative treatments that may have fewer side effects.

If the side effects you are experiencing are intolerable, it is crucial to communicate this with your doctor. There are alternative treatments for acne that may be less impactful on your hormonal balance. For instance, other medications like topical retinoids, antibiotics, or hormonal treatments such as oral contraceptives may be effective in managing acne without the same level of side effects as Androcur.

In summary, while Androcur can be effective for treating acne related to high testosterone levels, it is essential to weigh the benefits against the side effects you are experiencing. Open communication with your healthcare provider is key to finding the most suitable treatment plan for your condition. They can help you explore alternative options and monitor your health to ensure that your treatment is both effective and tolerable.

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