Positive Pap Smear Results After HPV Diagnosis - Obstetrics and Gynecology

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The smear test result is positive?


Last week, I discovered that I have genital warts.
After an examination, the doctor said it is not serious.
A week later, I received a call from the clinic informing me that my Pap smear results were positive.
I would like to know if this is related to having genital warts.
I have a single sexual partner and have received both the bivalent and quadrivalent vaccines.
I want to know if my Pap smear results will return to normal after the genital warts are treated.

P, 20~29 year old female. Ask Date: 2018/04/09

Dr. Huang Jianzhong reply Obstetrics and Gynecology


Last week, I discovered that I have genital warts.
After an examination, the doctor said it is not serious.
A week later, the clinic called to inform me that my Pap smear results were positive.
I would like to know if this is related to having genital warts.
I have a single sexual partner and have received both the bivalent and quadrivalent vaccines.
I want to know if my Pap smear will return to normal after the genital warts are treated.
Answer: 1.
A positive Pap smear result has various levels of significance; whether it is related to genital warts depends on the specific level.
2.
Whether the Pap smear will return to normal after the genital warts are treated also depends on the level of the positive Pap smear result.
3.
The quadrivalent vaccine is associated with genital warts, while the bivalent vaccine is not related to genital warts.

Reply Date: 2018/04/09

More Info


Understanding positive Pap smear results, especially in the context of HPV (Human Papillomavirus) diagnosis, can be quite complex. It’s important to clarify the relationship between HPV, abnormal Pap smear results, and the presence of genital warts (often referred to as "cauliflower" due to their appearance).
First, let's address the connection between HPV and your recent diagnosis of genital warts. Genital warts are caused by certain strains of HPV, specifically low-risk types such as HPV 6 and 11. These strains are typically not associated with cervical cancer but can lead to the development of warts. On the other hand, a Pap smear is a screening test designed to detect abnormal cells in the cervix, which can be caused by high-risk HPV types (like HPV 16 and 18) that are associated with cervical cancer.

Given that you have received a positive Pap smear result, it indicates that there are abnormal cells present on your cervix. This does not necessarily mean you have cervical cancer; rather, it suggests that further investigation is needed. The presence of genital warts does not directly correlate with the results of a Pap smear, but it does indicate that you have been infected with HPV.
You mentioned that you are in a monogamous relationship and have received both the bivalent and quadrivalent HPV vaccines. These vaccines are effective in protecting against the high-risk HPV types that can lead to cervical cancer and some low-risk types that cause genital warts. However, if you were exposed to HPV before vaccination, the vaccine would not eliminate the virus that is already present in your system.

Regarding your question about whether the Pap smear results will normalize after the genital warts have resolved, it is possible but not guaranteed. The resolution of warts does not automatically mean that the abnormal cells detected in the Pap smear will return to normal. The body can clear HPV infections over time, but this process can vary from person to person.
It is advisable to follow up with your healthcare provider for further evaluation. This may include a colposcopy, where a doctor examines your cervix more closely, and possibly a biopsy to determine the nature of the abnormal cells. Depending on the findings, your doctor may recommend a specific course of action, which could include monitoring, further testing, or treatment.

In summary, while there is a relationship between HPV, genital warts, and Pap smear results, they are distinct issues. The presence of genital warts indicates a low-risk HPV infection, while a positive Pap smear suggests the need for further investigation into potential high-risk HPV effects on cervical cells. It is essential to maintain regular follow-ups with your healthcare provider to monitor your cervical health and address any concerns you may have.

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