How to Safely Combine Red Yeast Rice and Fish Oil for Health - Nutrition

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Red yeast rice and fish oil?


Hello, Dietitian Tsai! I was recently diagnosed with an autoimmune condition known as Sjögren's syndrome.
I have been taking red yeast rice with Coenzyme Q10 due to slightly elevated low-density lipoprotein cholesterol levels.
However, I also want to incorporate fish oil to reduce inflammation in my immune system.
Could you please advise me on the correct way to take red yeast rice and fish oil? Their functions seem similar, and I'm concerned about potential side effects from taking both.
Thank you!

Vivian, 50~59 year old female. Ask Date: 2022/10/12

Dr. Cai Xiuwen reply Nutrition


Hello, regarding your inquiry, current research indicates that fish oil may have anti-inflammatory properties.
However, based on the literature I reviewed, there is no significant difference in the context of dry eye syndrome associated with dry eye disease.
It is generally recommended to use a dosage of fish oil around 1-2 grams per day.
Caution should be taken to avoid simultaneous use with dietary supplements or health products that may affect coagulation.
When selecting fish oil, it is advisable to choose products that have food safety certification.
If swallowing is difficult, pay attention to the size and concentration of the capsules.
This information is provided by Nantou Hospital, Ministry of Health and Welfare.
Wishing you health and safety.

Reply Date: 2022/10/12

More Info


When considering the combination of red yeast rice and fish oil for health, especially in the context of managing dry syndrome and high LDL cholesterol, it's essential to understand the individual benefits and potential interactions of these supplements.

Red Yeast Rice: This is a traditional Chinese medicine that contains monacolin K, which is chemically identical to the active ingredient in the prescription drug lovastatin. It is primarily used to lower cholesterol levels. Studies have shown that red yeast rice can effectively reduce LDL cholesterol and triglycerides, making it a popular choice for individuals looking to manage their cholesterol levels naturally. However, it is crucial to monitor liver function and muscle health, as red yeast rice can cause side effects similar to statins, including muscle pain and liver damage.

Fish Oil: Rich in omega-3 fatty acids, particularly EPA and DHA, fish oil is well-known for its anti-inflammatory properties. It can help reduce inflammation in the body, which is beneficial for autoimmune conditions like dry syndrome. Fish oil has also been shown to lower triglyceride levels and may have a positive effect on heart health. The typical recommended dosage for fish oil is between 1 to 2 grams per day, but this can vary based on individual health needs and conditions.

Combining Red Yeast Rice and Fish Oil: When combining these two supplements, it is essential to consider the following:
1. Dosage: Start with the lower end of the recommended dosages for both supplements. For red yeast rice, this might be around 600 mg to 1200 mg per day, and for fish oil, 1 gram per day. Monitor how your body responds before increasing the dosage.

2. Timing: Taking these supplements at different times of the day may help reduce the risk of gastrointestinal discomfort. For example, you could take red yeast rice in the morning and fish oil in the evening.

3. Monitoring Side Effects: Both supplements can affect liver function and blood clotting. It is vital to have regular check-ups with your healthcare provider to monitor liver enzymes and overall health, especially if you experience any unusual symptoms like muscle pain, weakness, or signs of bleeding.

4. Dietary Considerations: Ensure that your diet is rich in whole foods, including fruits, vegetables, whole grains, and lean proteins. This can enhance the effectiveness of both supplements and support your immune system.

5. Consultation with Healthcare Providers: Before starting any new supplement regimen, especially when dealing with conditions like dry syndrome and high cholesterol, consult with a healthcare provider or a registered dietitian. They can provide personalized advice based on your health history and current medications.

6. Quality of Supplements: Choose high-quality supplements that have been tested for purity and potency. Look for products that have been certified by third-party organizations to ensure they do not contain harmful contaminants.

In conclusion, while red yeast rice and fish oil can be beneficial for managing cholesterol levels and inflammation, it is crucial to approach their use thoughtfully and under the guidance of a healthcare professional. This will help maximize their health benefits while minimizing potential risks.

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