Your Diabetes Risk: Key Health Check Insights - Internal Medicine

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Questions related to diabetes?


Every year, I participate in my company's health check-up.
I am 35 years old, 179 cm tall, and weigh between 55 to 56 kg.
I have always been slim and unable to gain weight since childhood, and I maintain a regular exercise routine.
I have mild Mediterranean anemia.
This year's check-up results showed a fasting blood glucose level of 88 mg/dL (reference range: 70-100 mg/dL), which has been in the 80s in previous years.
My hemoglobin A1c was 5.9% (reference range: 4.0-6.0%), whereas it has been 5.6% to 5.7% in previous years.
My insulin resistance index, HOMA-IR, was 1.8 (reference range: <1.9), which is the first time I have had this test done.
Although all results are still within the reference range, I am concerned that this might indicate a potential issue.
The hemoglobin A1c has suddenly increased to 5.9% this year.
With an HOMA-IR of 1.8, I feel like I might be approaching insulin resistance.

To be honest, I do not usually consume sweets or sugary drinks; I mostly drink plain water and exercise regularly.
However, my physical activity has significantly decreased recently due to a COVID-19 diagnosis and the pandemic.
My waist circumference is only 74 cm, body fat percentage is 18.2%, and visceral fat is only 3 (with a standard of below 9).
I do not have high blood pressure or high cholesterol, and I do not exhibit the symptoms of metabolic syndrome.
I consulted a local clinic, and the doctor advised that since my results are within the standard range, there is no need for excessive concern, and it does not necessarily indicate prediabetes.
He suggested that I should just keep an eye on it.
However, I still feel uneasy.
I do not see myself as someone progressing towards diabetes, so I would like to seek a second opinion.
I hope you can provide me with some advice on what I should do.
Should I undergo more detailed testing, or should I wait until next year's health check-up? Or could the issue lie elsewhere?

Hsuān, 30~39 year old female. Ask Date: 2023/06/18

Dr. Li Jian reply Internal Medicine


You can undergo an oral glucose tolerance test at the Metabolism Clinic.
Thank you for your inquiry.

Reply Date: 2023/06/18

More Info


Understanding your diabetes risk is crucial, especially as you age and as lifestyle factors come into play. Based on the information you've provided, let's break down your health metrics and discuss your concerns.

At 35 years old, with a height of 179 cm and a weight of 55-56 kg, you have a Body Mass Index (BMI) of approximately 17.2, which is considered underweight. While being underweight can sometimes be associated with lower risks for certain conditions, it can also indicate underlying health issues, especially if you have a history of Mediterranean anemia and have experienced fluctuations in your weight.

Your recent health check results show:
- Fasting Blood Sugar: 88 mg/dL (normal range: 70-100 mg/dL)
- HbA1c: 5.9% (normal range: 4.0-6.0%)
- HOMA-IR: 1.8 (normal range: <1.9)
While all these values are within the normal range, the slight increase in your HbA1c from previous years (5.6-5.7% to 5.9%) is noteworthy. HbA1c is a critical marker for assessing long-term glucose control and can indicate how well your body is managing blood sugar levels over the past two to three months. An HbA1c of 5.9% is still considered normal, but it is on the higher end of the spectrum, which may suggest that you are approaching the threshold for prediabetes (which is defined as an HbA1c of 5.7% to 6.4%).

Your HOMA-IR score of 1.8 indicates that you are not insulin resistant at this time, as it is still below the threshold of 1.9. However, it does suggest that you should monitor this closely, especially since you mentioned a decrease in your physical activity due to health issues and the pandemic. Regular exercise is vital for maintaining insulin sensitivity and overall metabolic health.

Given your concerns, here are some recommendations:
1. Regular Monitoring: Continue to monitor your blood sugar levels and HbA1c annually. If you notice any significant changes or if you start experiencing symptoms such as increased thirst, frequent urination, or fatigue, consult your healthcare provider sooner.

2. Dietary Considerations: Even though you do not consume a lot of sugary foods or drinks, it’s essential to maintain a balanced diet rich in whole foods, including vegetables, lean proteins, whole grains, and healthy fats. Avoid processed foods and those high in refined sugars and trans fats, as they can contribute to insulin resistance over time.

3. Physical Activity: Aim to re-establish a regular exercise routine. Engaging in at least 150 minutes of moderate-intensity aerobic activity each week, along with strength training exercises, can significantly improve your insulin sensitivity and overall health.

4. Consult a Specialist: If you remain concerned about your risk for diabetes, consider consulting an endocrinologist or a specialist in metabolic health. They may recommend further testing, such as an Oral Glucose Tolerance Test (OGTT), to provide a more comprehensive assessment of your glucose metabolism.

5. Lifestyle Adjustments: Focus on maintaining a healthy lifestyle, including managing stress, getting adequate sleep, and avoiding smoking and excessive alcohol consumption, as these factors can also influence your risk for diabetes.

In conclusion, while your current metrics are within normal ranges, the upward trend in your HbA1c and your concerns about insulin resistance warrant attention. By taking proactive steps in monitoring your health and making lifestyle adjustments, you can significantly reduce your risk of developing diabetes in the future. Always feel free to seek a second opinion or further evaluations if you feel it necessary for your peace of mind.

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