Diabetes: How to Know if You're at Risk - Internal Medicine

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Diabetes mellitus


Hello Dr.
Chiu: Our family has a history of hereditary diseases.
My grandfather has diabetes and has been under your care for management.
Other family members are worried about the possibility of having diabetes, but they are unsure how to determine if they have diabetes.

BKK, 30~39 year old female. Ask Date: 2010/07/22

Dr. Qiu Zhengbin reply Internal Medicine


Hello, diabetes has a genetic component.
Since your grandfather has diabetes, his children are at risk for the condition.
Diabetes is characterized by the three P's: polyphagia (increased hunger), polydipsia (increased thirst), and polyuria (increased urination), along with weight loss.
However, about 30% of patients may be asymptomatic.
Screening is the safest approach; family members aged 40 and older or those who are obese should have their blood glucose tested annually.
You and your family are welcome to visit the Metabolism Clinic for screening.

Reply Date: 2010/07/22

More Info


Understanding your risk for diabetes, especially when there is a family history, is crucial for early intervention and prevention. Diabetes, particularly type 2 diabetes, has a strong genetic component, meaning that if a family member has it, your risk may be higher. For instance, if one parent has diabetes, the risk for their children is about 20%, and if both parents have it, the risk increases to 40-50%. However, genetics is just one piece of the puzzle; lifestyle factors play a significant role as well.

To assess your risk for diabetes, consider the following key factors:
1. Family History: As you mentioned, having a grandparent with diabetes increases your risk. It's important to be aware of other family members with diabetes as well, as this can provide insight into your genetic predisposition.

2. Age: The risk of developing type 2 diabetes increases with age, particularly after 45 years old. However, it can occur at any age, especially if other risk factors are present.

3. Body Weight: Being overweight or obese is a significant risk factor for type 2 diabetes. A Body Mass Index (BMI) of 25 or higher is considered overweight, and a BMI of 30 or higher is classified as obese. Maintaining a healthy weight can significantly reduce your risk.

4. Physical Activity: A sedentary lifestyle contributes to weight gain and increases the risk of diabetes. Regular physical activity helps maintain a healthy weight and improves insulin sensitivity. Aim for at least 150 minutes of moderate aerobic activity each week.

5. Diet: A diet high in processed foods, sugars, and unhealthy fats can increase diabetes risk. Focus on a balanced diet rich in whole grains, fruits, vegetables, lean proteins, and healthy fats. Monitoring carbohydrate intake is also essential, as it directly affects blood sugar levels.

6. Blood Pressure and Cholesterol Levels: High blood pressure (140/90 mmHg or higher) and abnormal cholesterol levels can increase the risk of diabetes. Regular check-ups can help monitor these levels.

7. Gestational Diabetes: If you or any female family members have had gestational diabetes, this increases the risk of developing type 2 diabetes later in life.

8. Other Health Conditions: Conditions such as polycystic ovary syndrome (PCOS), high triglycerides, and low HDL cholesterol can also increase diabetes risk.

To determine your current status regarding diabetes, consider the following steps:
- Regular Screening: If you have risk factors, it's essential to have regular screenings for blood glucose levels. The American Diabetes Association recommends that adults with risk factors be screened for diabetes every three years starting at age 45, or earlier if there are additional risk factors.

- Fasting Blood Glucose Test: This test measures your blood sugar after fasting for at least eight hours. A fasting blood sugar level of 100-125 mg/dL indicates prediabetes, while 126 mg/dL or higher suggests diabetes.

- Hemoglobin A1c Test: This test provides an average blood sugar level over the past two to three months. An A1c level of 5.7% to 6.4% indicates prediabetes, while 6.5% or higher suggests diabetes.

- Oral Glucose Tolerance Test (OGTT): This test measures blood sugar before and two hours after consuming a sugary drink. It can help diagnose diabetes or prediabetes.

If you are concerned about your risk, it may be beneficial to consult with a healthcare professional who can provide personalized advice based on your family history and lifestyle. They may recommend lifestyle changes, such as improving your diet and increasing physical activity, or they may suggest more frequent monitoring of your blood sugar levels.

In summary, understanding your risk for diabetes involves considering both genetic and lifestyle factors. Regular screenings and proactive health management can help you stay ahead of potential issues and maintain your health.

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