Can I Take My Antidepressant After Lunch Instead of Dinner? - Psychiatry

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Can Wellbutrin be taken after lunch?


Hello Doctor: Can I change the timing of taking my medication, Wellbutrin, from after dinner to after lunch? I am only taking one psychiatric medication.
Thank you.

Ava, 20~29 year old female. Ask Date: 2005/04/11

Dr. Chen Guangpeng reply Psychiatry


Hello Ava: The antidepressant known as Prozac has a half-life of over 72 hours, so it is sufficient to take it once a day.
When to take it depends on the side effects experienced from the medication.
Currently, in addition to the original manufacturer (Eli Lilly), there are many domestically produced options available.
Generally speaking, the original medication tends to have a stimulating effect in about 70-80% of patients, so it is often taken in the morning; however, most of the domestically produced versions seem to have a sedative effect (don't ask me why, I don't understand either), which can affect alertness and operational ability if taken during the day.
Therefore, the timing of medication should be based on your response, with the principle of not disrupting your daily routine.

Reply Date: 2005/04/11

More Info


When it comes to taking antidepressants, such as Effexor (venlafaxine), timing can be an important factor in maximizing the medication's effectiveness and minimizing side effects. Generally, it is crucial to follow your healthcare provider's instructions regarding when to take your medication. However, if you are considering changing the timing of your dose from after dinner to after lunch, there are several factors to consider.

First and foremost, it is essential to understand the pharmacokinetics of the medication. Effexor is an antidepressant that works by inhibiting the reuptake of serotonin and norepinephrine in the brain, which helps to alleviate symptoms of depression and anxiety. The medication can be taken once or twice daily, depending on the prescribed dosage. If you are currently taking it once daily after dinner, switching to after lunch may be feasible, but it is important to consult your prescribing physician before making any changes.

One of the primary reasons for taking medication at a specific time is to maintain consistent blood levels of the drug in your system. Taking Effexor after lunch instead of dinner may lead to fluctuations in the medication's concentration, which could potentially affect its efficacy. For instance, if you experience a dip in your mood or increased anxiety in the evening, taking the medication earlier in the day might help alleviate those symptoms. However, it is also possible that taking it earlier could lead to side effects, such as insomnia or increased anxiety, particularly if the medication's stimulating effects are more pronounced during the day.

Another consideration is the potential impact on your daily routine. If you find that taking the medication after lunch fits better into your schedule and helps you remember to take it consistently, that could be a valid reason to make the change. However, you should monitor how you feel after making this adjustment. If you notice any changes in your mood, energy levels, or side effects, it is crucial to report these to your healthcare provider.

Additionally, some individuals may experience gastrointestinal side effects when starting or adjusting the dosage of Effexor. Taking the medication with food can sometimes help mitigate these effects. If you find that taking it after lunch reduces any nausea or discomfort you may have experienced when taking it after dinner, this could be another reason to consider the change.

In summary, while it may be possible to take your antidepressant after lunch instead of dinner, it is essential to discuss this change with your healthcare provider. They can provide personalized advice based on your specific situation, including your current dosage, how well the medication is working for you, and any side effects you may be experiencing. Remember, consistency is key in managing depression and anxiety, so any changes to your medication regimen should be made thoughtfully and under professional guidance.

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