Skin Reactions After Using ZORAC: What You Need to Know - Dermatology

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Post-medication issues?


Hello Dr.
Jiang,
I am one of your outpatient patients.
During my follow-up appointment on November 21, after the skin biopsy and suture removal, you prescribed ZORAC (tazarotene) cream.
After applying it for three days, the treated area has developed peeling, redness, swelling, itching, and pain.
Is this a normal reaction? Can I continue using the cream, or should I return to the hospital for you to examine it? Thank you!

Liu Xiansheng, 30~39 year old female. Ask Date: 2005/11/26

Dr. Jiang Zheen reply Dermatology


You can stop the medication for a few days.
Zorac is a type of retinoid that may cause peeling, so wait until your skin recovers before applying a small amount.
If you have any questions, please call me at 038358141-3116.
Wishing you peace, and Jesus loves you.

Reply Date: 2005/11/26

More Info


When using ZORAC (tazarotene), a topical retinoid commonly prescribed for acne and other skin conditions, it is not uncommon to experience some skin reactions, especially during the initial stages of treatment. The symptoms you described—peeling, redness, itching, and pain—are known side effects associated with retinoid use. These reactions occur as the skin adjusts to the medication, which works by promoting cell turnover and preventing the clogging of pores.


Understanding the Side Effects
1. Peeling and Redness: These are typical reactions as the skin undergoes a process of exfoliation. Tazarotene accelerates the shedding of dead skin cells, which can lead to temporary irritation. This is particularly common in the first few weeks of treatment.

2. Itching and Pain: Itching can occur due to the increased sensitivity of the skin as it adjusts to the medication. Pain may also be a result of irritation, especially if the skin barrier is compromised.

3. Duration of Symptoms: Generally, these side effects may improve after a few days to weeks as your skin acclimates to the medication. However, if the symptoms persist or worsen, it is essential to consult your healthcare provider.


Recommendations for Managing Side Effects
1. Discontinue Use Temporarily: If the irritation is severe, it is advisable to stop using ZORAC for a few days to allow your skin to recover. This will help reduce inflammation and discomfort.

2. Moisturize: Applying a gentle, non-comedogenic moisturizer can help soothe the skin and restore the skin barrier. Look for products that are fragrance-free and designed for sensitive skin.

3. Reintroduce Gradually: Once your skin has calmed down, you can reintroduce ZORAC slowly. Start by applying a small amount every other day or even less frequently until your skin adjusts.

4. Consult Your Doctor: If you are uncertain about continuing the medication or if your symptoms do not improve, it is crucial to return to your healthcare provider for further evaluation. They may adjust your treatment plan or suggest alternative therapies.


When to Seek Immediate Medical Attention
If you experience severe reactions such as blistering, extensive swelling, or signs of an allergic reaction (such as difficulty breathing or swelling of the face), seek medical attention immediately. These symptoms could indicate a more serious condition that requires prompt intervention.


Conclusion
In summary, while the side effects you are experiencing after using ZORAC can be concerning, they are not uncommon. It is essential to listen to your body and take appropriate measures to manage these reactions. Always keep an open line of communication with your healthcare provider regarding any concerns or persistent symptoms. They are best equipped to guide you through your treatment and ensure the health of your skin.

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