Bile Acid pH Levels and Dietary Treatment for Gallstones - Nutrition

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What is the pH value of bile acids?


What is the pH value of bile acids? Is it 8-9? If so, why are they called acids? Can dietary treatment be used for gallstones? Thank you.

Elaine, 20~29 year old female. Ask Date: 2006/02/21

Dr. Shi Guimei reply Nutrition


Hello! Bile acids are referred to as acids due to the presence of carboxyl groups (-COOH), but their pH value is not readily available in many related textbooks and resources.
Dietary factors may be associated with the formation of gallstones, such as obesity, high-calorie diets, low-fiber diets, and prolonged fasting (such as frequently skipping breakfast).
For gallstones, a low-fat diet is recommended (avoiding greasy, fried, high-fat desserts, and meat) to reduce the stimulation of the gallbladder by fatty foods.
During an acute episode of gallstones, a low-fat clear liquid diet can be adopted along with intravenous hydration.
Subsequently, skim milk, fruit juices, and porridge can be introduced as liquid foods, gradually progressing to low-fat soft foods, while paying attention to the supplementation of fat-soluble vitamins.
Sincerely, Dietitian Shih Kuei-Mei, Director of the Nutrition Department, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2006/02/21

More Info


Bile acids are crucial components of bile, which is produced by the liver and stored in the gallbladder. They play a significant role in the digestion and absorption of fats and fat-soluble vitamins in the small intestine. The pH of bile acids is not straightforward to define as a single value, as bile is a complex mixture of bile acids, salts, cholesterol, bilirubin, and other substances. Generally, bile has a pH that ranges from 7 to 8, which is slightly alkaline. The term "acid" in bile acids refers to their chemical structure, which contains carboxylic acid groups (-COOH). This is why they are classified as acids despite the overall alkaline nature of bile.

Regarding gallstones, they can form when there is an imbalance in the substances that make up bile. Factors such as high cholesterol levels, insufficient bile salts, and the presence of bilirubin can contribute to gallstone formation. Dietary factors can indeed influence the risk of developing gallstones. A diet high in saturated fats and cholesterol, low in fiber, and characterized by long periods of fasting can increase the likelihood of gallstone formation.
For individuals with gallstones, dietary modifications can be beneficial. A low-fat diet is often recommended, particularly during acute episodes of gallbladder inflammation or pain. This includes avoiding greasy, fried foods and high-fat meats. Instead, a diet rich in fruits, vegetables, whole grains, and lean proteins is encouraged. Foods high in fiber can help reduce cholesterol levels and promote healthy digestion, potentially reducing the risk of gallstones.

In cases of acute gallbladder attacks, a clear liquid diet may be recommended initially, followed by a gradual reintroduction of low-fat, soft foods. It's essential to ensure adequate hydration and to monitor the intake of fat-soluble vitamins, as a low-fat diet can impact their absorption.

While dietary changes can help manage symptoms and reduce the risk of gallstones, they are not a guaranteed treatment for existing stones. In some cases, medical intervention may be necessary, especially if the stones cause significant pain or complications.
In summary, while the pH of bile acids is slightly alkaline, the term "acid" refers to their chemical structure. Dietary modifications can play a role in managing gallstones, focusing on a low-fat, high-fiber diet to reduce symptoms and prevent further stone formation. However, it is crucial to consult with a healthcare professional for personalized advice and treatment options.

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