Is Fushuganlong Capsule Safe for G6PD Patients? Side Effects Explained

Medications

Is this medication safe for patients with G6PD deficiency? Chinese name: Fushuganlong Capsules Ingredients: Acetaminophen..........300mg Chlorpheniramine Maleate.........2.5mg Dextromethorphan Hydrobromide.....15mg dl-Methylephedrine Hydrochloride......10mg Potassium Guaiacol Sulfonate.......60mg Caffeine Anhydrous.........30mg Thiamine Hydrochloride..........8mg Riboflavin...........4mg This medication is registered under the number 026818.
Does this medication have any other side effects?

Wei, 10~19 year old female. Ask Date: 2006/10/18

Dr. Cai Jueren reply Family Medicine

Hello, we advise against the use of the aforementioned medications for patients with G6PD deficiency.
All medications should be prescribed by a physician, and it is best not to purchase over-the-counter drugs without guidance.
The following substances can cause oxidative agents that lead to hemolysis: (1) antimalarial drugs, (2) sulfonamides found in certain antibiotics, (3) some analgesics such as the well-known aspirin, and certain medications previously used to treat urinary tract infections.
Additionally, some chemicals such as camphor balls, gentian violet, and methylene blue can also cause hemolysis.
In terms of food, children with this condition often experience acute hemolytic anemia after consuming fava beans and their products, which is why this condition is commonly referred to as fava bean disease.
Thank you for your inquiry, and we hope this information resolves your concerns.
Dr.
Chai Jue-ren, Hualien Hospital.

Reply Date: 2006/10/18

More Info

Fushuganlong Capsule, known as 福舒感朗膠囊, is a combination medication primarily used for the relief of cold and flu symptoms. Its ingredients include Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, dl-Methylephedrine Hydrochloride, Potassium Guaiacol Sulfonate, Caffeine Anhydrous, Thiamine Hydrochloride, and Riboflavin. When considering the safety of this medication for patients with G6PD deficiency, it is essential to analyze its components and their potential effects.

G6PD deficiency is a genetic condition that affects the enzyme glucose-6-phosphate dehydrogenase, which plays a crucial role in protecting red blood cells from oxidative damage. Patients with this deficiency are at risk of hemolytic anemia when exposed to certain medications, foods, or infections. Therefore, it is vital for G6PD patients to avoid specific drugs known to trigger hemolysis.

1. Acetaminophen: Generally considered safe for G6PD patients, acetaminophen is a common analgesic and antipyretic. However, excessive doses can lead to liver toxicity, which is a concern for all patients, not just those with G6PD deficiency.

2. Chlorpheniramine Maleate: This is an antihistamine that can cause sedation and dry mouth. It does not have a known association with hemolytic reactions in G6PD patients, making it relatively safe.

3. Dextromethorphan Hydrobromide: This is a cough suppressant and is also considered safe for G6PD patients. There are no documented adverse effects related to hemolysis.

4. dl-Methylephedrine Hydrochloride: This is a decongestant that can increase heart rate and blood pressure. While not specifically contraindicated for G6PD patients, caution is advised due to its stimulant effects.

5. Potassium Guaiacol Sulfonate: This is an expectorant, and there is limited information regarding its safety in G6PD patients. However, it is not commonly associated with hemolytic reactions.

6. Caffeine Anhydrous: Caffeine is generally safe for G6PD patients, but it can cause increased heart rate and anxiety in some individuals.

7. Thiamine Hydrochloride and Riboflavin: These are vitamins and are safe for G6PD patients.

In summary, Fushuganlong Capsule contains ingredients that are generally considered safe for G6PD patients. However, the potential for individual reactions cannot be entirely ruled out, and patients should always consult with their healthcare provider before starting any new medication.

Side Effects of Fushuganlong Capsule
The side effects associated with Fushuganlong Capsule may include:
- Drowsiness: Due to the presence of antihistamines.

- Dry Mouth: Common with many antihistamines.

- Fatigue: Some users may experience tiredness.

- Visual Disturbances: Rarely, some may experience blurred vision.

- Confusion: Particularly in older adults or those taking other sedatives.

- Urinary Retention: Can occur, especially in men with prostate issues.

- Increased Heart Rate: Due to the stimulant properties of methylephedrine and caffeine.

- Allergic Reactions: Though rare, some individuals may experience skin rashes or other allergic symptoms.

Recommendations for G6PD Patients
1. Consult Your Doctor: Always inform your healthcare provider about your G6PD status before taking any new medications.

2. Monitor Symptoms: If you experience any unusual symptoms after taking the medication, seek medical attention immediately.

3. Avoid Self-Medication: Do not take over-the-counter medications without consulting a healthcare professional, as some may contain ingredients that could trigger hemolysis.

In conclusion, while Fushuganlong Capsule appears to be safe for G6PD patients based on its components, individual responses can vary. It is crucial to approach any medication with caution and under the guidance of a healthcare provider.

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