Is Hyaluronic Acid Injection a Suitable Alternative to Knee Replacement? - Orthopedics

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Is it possible to inject hyaluronic acid for knee joint pain?


Four years ago, I had a knee replacement surgery on my right knee, and it has been very successful without any complications.
However, recently I have developed bone spurs in my left knee, which are causing pain.
I am currently receiving a hyaluronic acid injection every week and have had three injections so far, with some improvement in my symptoms.
Should I continue with the hyaluronic acid injections and avoid knee replacement surgery? Is this an appropriate approach?

A-Xia, 60~69 year old female. Ask Date: 2007/05/11

Dr. Luo Zhongwei reply Orthopedics


Dear A-Hsia,
Regarding your inquiry, since I am not aware of your X-ray examination results and actual age, I can only provide the following explanation based on health insurance regulations: According to health insurance guidelines, if a patient is over 60 years old and the X-ray assessment of the knee joint indicates a certain level of severity, the physician may prescribe glucosamine (medication) for treatment.
If there is no improvement in symptoms after three months of continuous use, a course of five hyaluronic acid injections (one injection per week) may be administered.
As for your question about whether to continue hyaluronic acid injections or consider joint replacement surgery, I recommend that you consult with an orthopedic specialist who can discuss your current situation and make a decision accordingly.

Reply Date: 2007/05/11

More Info


Hyaluronic acid (HA) injections have gained popularity as a treatment option for knee osteoarthritis, particularly for patients who experience pain and discomfort due to conditions like bone spurs. In your case, having undergone a successful knee replacement four years ago and now facing issues with your left knee, it’s understandable to seek alternatives to more invasive procedures like knee replacement surgery.

Hyaluronic acid is a naturally occurring substance in the body, primarily found in connective tissues, skin, and synovial fluid, which lubricates joints. The primary purpose of HA injections is to supplement the viscosity and elasticity of the synovial fluid in the knee joint, potentially providing relief from pain and improving joint function. These injections are often considered when conservative treatments, such as physical therapy, weight management, and oral medications, have failed to provide adequate relief.

In your situation, you mentioned that you have already received three HA injections, with some improvement in your symptoms. This is a positive sign, as many patients report varying degrees of relief from HA therapy. The typical treatment regimen for HA injections involves a series of one to five injections, depending on the specific product used and the severity of the condition. Some patients find that they can achieve significant pain relief and improved mobility without resorting to surgery.

However, it is crucial to understand that HA injections are not a permanent solution. The effects typically last from several weeks to a few months, and the need for repeat injections may arise. While some patients may benefit from ongoing HA therapy, others may eventually require more definitive treatments, such as knee replacement, especially if the underlying joint degeneration progresses.

Regarding your question about whether to continue with HA injections or consider knee replacement, it is essential to weigh the benefits and limitations of each option. If you are experiencing significant improvement in your symptoms and can maintain a functional level of activity, continuing with HA injections may be appropriate. However, if your symptoms worsen or if you find that your quality of life is significantly impacted, it may be time to discuss surgical options with your orthopedic surgeon.

It is also important to note that while HA injections can provide symptomatic relief, they do not address the underlying structural issues in the joint. Therefore, ongoing monitoring of your knee's condition through imaging studies and regular consultations with your orthopedic specialist is advisable.

In summary, hyaluronic acid injections can be a suitable alternative to knee replacement for some patients, particularly in the early to moderate stages of osteoarthritis. However, the decision to continue with HA therapy or to consider knee replacement should be made in consultation with your orthopedic surgeon, taking into account your specific symptoms, overall health, and lifestyle goals. Regular follow-ups and open communication with your healthcare provider will ensure that you receive the most appropriate care tailored to your needs.

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