Are Grape Seeds Healthy? Debunking Myths About Eating Grapes - Family Medicine

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Regarding the issue of eating grapes?


Hello Director Wang: I really enjoy eating grapes, including the skin and seeds, but recently I came across an article online that stated the following: "In addition to the health benefits of OPCs found in grape seeds, there are also some harmful substances such as tannins that can be toxic.
Chewing and swallowing grape seeds directly may cause severe gastrointestinal irritation, leading to side effects like peptic ulcers.
Moreover, the percentage of OPCs in natural grape seeds is only about 1%.
To obtain 50 mg of pure OPCs, one would need to consume nearly six grams of grape seeds, which is equivalent to about three pounds of grapes with seeds.
Based on the optimal recommended amount of 100 mg of OPCs per day, a person would need to eat five to six pounds of grape seeds daily to obtain sufficient OPCs from natural grapes.
Therefore, sometimes certain natural health benefits may not be best obtained through consuming whole foods, and concentrated extracts of health food components still hold their value." My question is, according to this article, it seems that eating grapes may not be very beneficial and could even be harmful.
However, the knowledge I have gained since childhood suggests that consuming natural fruits is better for health.
This article seems to contradict that! Is it really true that one must purchase these health supplements to obtain the nutrients from grapes? Or is this just a marketing gimmick? I am quite confused, and I would appreciate your clarification.
Thank you!

Xiao Jie, 20~29 year old female. Ask Date: 2008/07/24

Dr. Wang Zhengzhong reply Family Medicine


Hello: You came across an article online stating that besides the health-beneficial OPCs found in grape seeds, there are also some harmful substances such as tannins that can be toxic.
Chewing and swallowing grape seeds directly may cause severe gastrointestinal irritation and lead to side effects like peptic ulcers.
Therefore, sometimes certain natural health-promoting components are not necessarily suitable for obtaining through natural food sources.
Concentrated extracts of health food ingredients still have their value.
This reminds me of a mention by an academician from the Academia Sinica during my residency, discussing how catechin green tea polyphenols extracted from tea leaves have antioxidant properties that can prevent cancer, but it requires a significant amount that is impossible to achieve through regular tea brewing, and purification is key.
I share the sentiment regarding the "marketing hype" of manufacturers, as oxygenating agents (such as OPC from pine bark, grape seed OPC, catechin green tea polyphenols, vitamin C, and beta-carotene) all have similar effects.
Moreover, the human body only requires trace amounts of vitamins or minerals to meet physiological needs; excessive intake can lead to adverse side effects and even toxicity.
For example, the Toxicology Department at Taipei Veterans General Hospital reported cases of vitamin A toxicity due to excessive consumption of deep-sea fish liver.

Reply Date: 2008/07/24

More Info


Grapes are a popular fruit known for their sweet taste and numerous health benefits. However, there are some misconceptions surrounding grape seeds and their nutritional value. Let's delve into the claims made in the article you referenced and clarify the facts about grape seeds and grapes in general.

Firstly, grape seeds contain a compound known as oligomeric proanthocyanidin complexes (OPCs), which are powerful antioxidants. These compounds are believed to provide various health benefits, including reducing inflammation, improving cardiovascular health, and potentially offering anti-cancer properties. However, the article you read suggests that grape seeds also contain tannins, which can be harmful in large amounts and may irritate the gastrointestinal tract. While it is true that excessive consumption of tannins can lead to digestive issues, the amount found in a typical serving of grapes or grape seeds is generally not enough to cause harm for most people.

The article also mentions that to obtain a significant amount of OPCs from grape seeds, one would need to consume an impractical quantity of grapes—around five to six pounds. This is an important point. While grape seeds do contain beneficial compounds, the concentration of these compounds is relatively low compared to the amount of fruit one would need to consume. This is why some people choose to take concentrated supplements that contain higher doses of OPCs. However, this does not mean that eating whole grapes is ineffective or harmful. Whole fruits provide a variety of nutrients, including vitamins, minerals, and fiber, which are essential for overall health.

Moreover, the idea that one must rely solely on supplements to gain the benefits of fruits is misleading. Whole fruits, including grapes, offer a balanced array of nutrients that work synergistically to promote health. Eating a variety of fruits and vegetables is the best way to ensure you are getting a wide range of nutrients. Supplements can be beneficial in certain situations, such as when someone has specific deficiencies or health conditions, but they should not replace whole foods in a balanced diet.

In terms of safety, eating grapes, including the skin and seeds, is generally safe for most individuals. If you enjoy eating grapes with the seeds, there is no need to stop unless you experience discomfort. If you have a sensitive stomach or digestive issues, it might be wise to consume them in moderation or consult a healthcare professional.

As for the notion that natural foods are always better than supplements, it is essential to recognize that both have their place in a healthy diet. Whole foods provide a complex matrix of nutrients that supplements cannot fully replicate. However, there are instances where supplements can play a crucial role, especially for individuals with specific dietary restrictions or health conditions.

In conclusion, grapes are a nutritious fruit that can be part of a healthy diet. Eating them whole, including the seeds, is generally safe and beneficial. While grape seeds do contain some beneficial compounds, the best approach to nutrition is to consume a variety of whole foods rather than relying solely on supplements. If you have specific health concerns or dietary needs, it is always best to consult with a healthcare professional or a registered dietitian for personalized advice.

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