Is PRP Therapy a Safer Alternative to Knee Replacement Surgery? - Orthopedics

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Knee pain


My mother-in-law is experiencing knee pain, and the doctor has suggested joint replacement.
Recently, I came across the PRP (Platelet-Rich Plasma) therapy that has been introduced in the country.
I would like to know if the risks are lower compared to surgery and if the effectiveness is good.
Does National Taiwan University Hospital in Hsinchu offer this treatment? Or does Kaohsiung Veterans General Hospital provide it as well? Thank you for your guidance!

Amy, 50~59 year old female. Ask Date: 2013/04/08

Dr. Shi Guozheng reply Orthopedics


The treatment method of PRP (platelet-rich plasma) has been recently proposed and is said to be helpful for certain bone or ligament injuries; however, it lacks large-scale clinical trials.
Reports from abroad indicate that it is a promising, but not proven treatment option for joint injuries.
Currently, this procedure is just being promoted domestically, and while it carries some risks, the risks associated with PRP injections are relatively lower, though effectiveness is not guaranteed.
You may need to check online for hospitals that offer this service.

Reply Date: 2013/04/08

More Info


Platelet-Rich Plasma (PRP) therapy has gained popularity in recent years as a potential treatment option for various musculoskeletal conditions, including knee pain and osteoarthritis. It involves extracting a small amount of the patient’s blood, processing it to concentrate the platelets, and then injecting this platelet-rich plasma into the affected area. The goal is to promote healing and reduce pain by utilizing the body’s natural growth factors found in platelets.

When considering whether PRP therapy is a safer alternative to knee replacement surgery, it's essential to understand the context of each treatment. Knee replacement surgery, particularly total knee arthroplasty, is typically recommended for patients with severe osteoarthritis or significant joint damage that has not responded to conservative treatments. While knee replacement can provide substantial pain relief and improved function, it is an invasive procedure that carries risks such as infection, blood clots, and complications related to anesthesia. Recovery can also be lengthy, requiring physical therapy and rehabilitation.

On the other hand, PRP therapy is a minimally invasive procedure, which means it generally has a lower risk profile compared to surgery. The side effects associated with PRP are typically mild and can include pain at the injection site, swelling, or temporary worsening of symptoms. However, the effectiveness of PRP therapy can vary significantly among individuals, and while some patients report substantial relief, others may experience minimal improvement. Research has shown that PRP can be beneficial for certain conditions, particularly in the early stages of osteoarthritis or for soft tissue injuries, but its efficacy in advanced osteoarthritis or severe joint degeneration is still under investigation.

In terms of safety, PRP therapy is considered to have a lower risk of serious complications compared to knee replacement surgery. However, it is crucial to note that PRP is not a guaranteed solution and may not be suitable for everyone. Patients with advanced osteoarthritis or significant structural damage to the knee may still require surgical intervention for optimal outcomes.

Regarding the availability of PRP therapy, many hospitals and clinics in Taiwan, including those affiliated with National Taiwan University Hospital in Hsinchu and Kaohsiung Veterans General Hospital, offer PRP treatments. It is advisable to consult with orthopedic specialists at these institutions to discuss the potential benefits and limitations of PRP therapy in your specific case. They can provide a thorough evaluation of your knee condition and help determine whether PRP is a viable option or if knee replacement surgery is the more appropriate course of action.

In conclusion, while PRP therapy presents a less invasive alternative to knee replacement surgery with a potentially lower risk profile, its effectiveness can vary, and it may not be suitable for all patients. A comprehensive assessment by a qualified healthcare professional is essential to determine the best treatment plan tailored to the individual’s needs and medical history.

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