Is It Safe to Take Natto and Red Yeast Rice with Medications? - Pharmacology

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Questions about natto and red yeast rice?


I would like to ask again, is it appropriate to take natto and red yeast rice now, considering that I have never taken them before and I started my current medication two months ago? Should I space out the timing of taking them with my prescription medications? Are there any potential interactions?

john, 50~59 year old female. Ask Date: 2013/11/11

Dr. Huang Shenggang reply Pharmacology


Hello, thank you for your follow-up question.
Based on the medications you provided last time, there doesn't appear to be any direct interactions at first glance.
However, for safety, it would be best to have your pharmacist review them.

Reply Date: 2013/11/11

More Info


When considering the safety of taking natto and red yeast rice while on medication, it's essential to understand the potential interactions and effects these foods may have on your health and the efficacy of your medications. Natto, a fermented soybean product, is rich in vitamin K2, which plays a crucial role in blood clotting. If you are on anticoagulant medications (blood thinners), such as warfarin, consuming natto could interfere with the medication's effectiveness, as vitamin K can counteract the effects of these drugs. Therefore, it is advisable to consult with your healthcare provider before introducing natto into your diet.

Red yeast rice, on the other hand, is often used as a natural supplement for lowering cholesterol levels. It contains monacolin K, which is chemically identical to the active ingredient in the prescription medication lovastatin. If you are already taking statin medications for cholesterol management, adding red yeast rice could lead to an increased risk of side effects, such as muscle pain or liver damage, due to the cumulative effect of the statins. Therefore, it is crucial to discuss with your doctor whether it is safe to take red yeast rice alongside your current medications.

In terms of timing, it is generally a good practice to space out the consumption of supplements and medications to minimize the risk of interactions. For instance, if you take your medications in the morning, you might consider taking natto or red yeast rice at a different time of day. However, the specific timing can depend on the medications you are taking, so it is best to follow your healthcare provider's advice.

Moreover, individual responses to foods and supplements can vary significantly. Some individuals may tolerate natto and red yeast rice without any issues, while others may experience adverse effects or interactions. Therefore, monitoring your body's response after introducing these foods is essential.

In conclusion, while natto and red yeast rice can offer health benefits, their safety in conjunction with medications depends on various factors, including the specific medications you are taking, your overall health status, and any underlying conditions. Always consult with your healthcare provider or a clinical pharmacist before making any changes to your diet or supplement regimen, especially when you are on medication. They can provide personalized advice based on your medical history and current treatment plan, ensuring that you make informed decisions about your health.

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