Abnormal Pap Smear Results and HPV: What You Need to Know - Obstetrics and Gynecology

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Cervical Pap smear results


Hello Doctor, I had my first Pap smear in June this year, and the result was 4.ASC-US.
Following the doctor's recommendation, I underwent a human papillomavirus (HPV) test, which came back positive with a value of 9.04 for type 56, indicating a low viral load.
The doctor did not provide much explanation and suggested I go to a larger hospital for a biopsy.
At the larger hospital, I had a colposcopy and two small biopsies taken.
The only information I received was verbally from the doctor, stating that it was inflammation.
I was given a seven-day course of suppositories, but I still have many questions and fears.
If it is just inflammation, why was the Pap smear result not categorized under inflammation? The Pap smear result was in category four, while the biopsy result indicated inflammation.
Is this situation concerning? Is a seven-day course of suppositories sufficient for the inflammation? During those seven days, my vagina was filled with discharge; does this mean the medication was not absorbed?

Yuan Yuan, 30~39 year old female. Ask Date: 2015/09/28

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, the results of your Pap smear show 4.ASC-US, which indicates that the cells appear abnormal, and the pathologist could not determine whether they are normal or abnormal.
Therefore, you underwent further testing, and the final result is cervicitis, which is the best outcome.
The usual treatment for cervicitis is the administration of vaginal suppositories.
I recommend that you follow up with monitoring and repeat Pap smears.
Wishing you good health.

Reply Date: 2015/09/28

More Info


Understanding abnormal Pap smear results and HPV can be quite overwhelming, especially when faced with medical jargon and the potential implications for your health. Let's break down your situation step by step.


Pap Smear Results and HPV
Your initial Pap smear result of ASC-US (Atypical Squamous Cells of Undetermined Significance) indicates that there are some abnormal cells present, but it does not necessarily mean that you have cancer. This result is often a signal for further investigation, which is why your doctor recommended an HPV test. The HPV test came back positive for HPV type 56, which is considered a high-risk type associated with cervical cancer, although the viral load was low.


Understanding the Follow-Up
The recommendation to undergo a colposcopy and biopsy at a larger hospital is standard practice when a Pap smear shows abnormal results. During the colposcopy, your doctor would have examined your cervix more closely and taken biopsies from areas that appeared abnormal. The fact that the biopsy results indicated inflammation is a positive sign, as it suggests that there may not be any significant dysplasia (precancerous changes) present. Inflammation can occur for various reasons, including infections, irritation, or other benign conditions.


Discrepancy Between Results
You mentioned a discrepancy between the Pap smear result and the biopsy findings. It’s important to understand that Pap smears and biopsies assess different aspects of cervical health. A Pap smear is a screening tool that looks for abnormal cells, while a biopsy provides a definitive diagnosis of the tissue sampled. Inflammation can cause changes in the cells that might lead to an ASC-US result, but it does not necessarily indicate the presence of a more serious condition.


Treatment and Management
Regarding the treatment with vaginal suppositories for seven days, this is a common approach to manage inflammation or infection. The suppositories are designed to deliver medication directly to the affected area, and while it may seem like there is a lot of discharge, this is often normal. The discharge can be a result of the medication itself, and it does not necessarily mean that the medication is not being absorbed. If you have concerns about the effectiveness of the treatment, it’s best to follow up with your healthcare provider for further evaluation.


Next Steps
1. Follow-Up: It’s crucial to have a follow-up appointment with your healthcare provider to discuss the results of your biopsy and any further steps needed. They can clarify the implications of the inflammation and whether additional treatment or monitoring is necessary.

2. HPV Vaccination: If you haven’t already, consider discussing the HPV vaccine with your doctor. The vaccine can protect against the most common high-risk HPV types and may help reduce the risk of developing cervical cancer in the future.

3. Regular Screening: Continue with regular Pap smears and HPV testing as recommended by your healthcare provider. This is essential for monitoring any changes in your cervical health.

4. Communication: Don’t hesitate to ask your doctor any questions you have about your results or treatment. Understanding your health is vital, and your healthcare provider should be willing to explain things in a way that makes sense to you.


Conclusion
In summary, while receiving an abnormal Pap smear result and a positive HPV test can be concerning, it’s important to remember that these are just parts of a larger picture. The subsequent findings of inflammation from your biopsy are a positive indication, and with proper follow-up and management, you can maintain your cervical health. Always keep an open line of communication with your healthcare provider to ensure you are well-informed and comfortable with your treatment plan.

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