Exploring the Benefits and Risks of Nucleic Acid Supplements

Could you please provide more details regarding dietary supplements?

Hello, Dietitian Tsai Hsiu-Wen: First of all, thank you very much for your detailed explanation.
I appreciate your hard work.
Thank you! The company Fuzhizhi from Japan primarily offers a nucleic acid beverage called Natural DN Collagen.
Its main ingredients are salmon fish essence extract (containing DNA), along with edible yeast extract (containing RNA and glutathione), collagen peptides, shark cartilage extract, vitamins (C, B1, B2, B6, B12), and zinc yeast.
It is claimed that the Natural DN Collagen nucleic acid beverage can repair cells and inhibit the growth of cancer cells.
It is also said to alter allergic conditions.
Some individuals have reported improvements in nasal allergies after consumption.
Others with shoulder and neck pain or back myofascial pain have also experienced relief.
I would like to ask Dietitian Tsai Hsiu-Wen, can this really repair cells and inhibit the growth of cancer cells? Is it truly as miraculous as it sounds? Can it really alleviate nasal allergies, shoulder and neck pain, and back myofascial pain? Are there any side effects associated with drinking this? Thank you! Thank you!

Mr. Chen, 40~49 year old female. Ask Date: 2018/07/14

Dr. Cai Xiuwen reply Nutrition

Hello! Currently, there are no relevant studies indicating that nucleic acids can inhibit cancer cell growth.
In Taiwan, nutritional health components are categorized into food, health foods, and pharmaceutical-grade products, each with different ingredients and regulations.
Generally speaking, the foundation of good health lies in a balanced intake of nutrients and appropriate exercise.
If lifestyle habits are not adjusted and diet is irregular, issues such as allergies, pain, and inflammation are unlikely to be completely resolved by consuming a specific health product.
Even high-dose medications with therapeutic effects cannot cure all diseases.

Is there a possibility of side effects from consuming such products? Essentially, if a product has not passed the review for health foods or pharmaceuticals, it can only be classified as food.
General food regulations cover aspects such as food additives, origin, manufacturers, importers, manufacturing dates, and expiration dates.
Therefore, if a product complies with general food regulations, it is generally safe for the public when consumed in moderation.
However, if it claims to inhibit cancer cells or repair tissues, it fundamentally violates regulations.

Product marketing needs to resonate with public concerns to gain attention, but misleading marketing can lead the public to spend significant amounts on supplements that may be unhelpful or even harmful.
It is often said that food is better than medicine; thus, I recommend a balanced diet with natural ingredients and a healthy lifestyle adjustment as the best approach.
Wishing you peace and health.

This response is from Dietitian Tsai Hsiu-Wen at Nantou Hospital, Ministry of Health and Welfare.

Reply Date: 2018/07/14

More Info

Nucleic acid supplements, particularly those derived from natural sources such as fish and yeast, have gained popularity in recent years due to claims of various health benefits. These supplements typically contain DNA and RNA, which are essential components of all living cells. The primary claims surrounding these supplements include cellular repair, cancer cell inhibition, and alleviation of allergic reactions and musculoskeletal pain. However, it is essential to critically evaluate these claims based on current scientific understanding.

Benefits of Nucleic Acid Supplements
1. Cellular Repair: Nucleic acids play a crucial role in cellular functions, including repair and replication. Some proponents suggest that supplementing with nucleic acids can enhance the body's ability to repair damaged cells. While it is true that nucleic acids are vital for cellular processes, the body is generally capable of synthesizing its own nucleic acids from dietary sources. Therefore, the direct impact of additional nucleic acids from supplements on cellular repair remains inconclusive.

2. Cancer Cell Inhibition: Some studies have suggested that certain nucleic acid compounds may have anti-cancer properties. For instance, RNA molecules can influence gene expression and potentially inhibit the growth of cancer cells. However, the evidence is still limited, and more rigorous clinical trials are needed to establish any definitive benefits of nucleic acid supplements in cancer prevention or treatment.

3. Allergy Relief: Anecdotal reports suggest that nucleic acid supplements may help alleviate allergic symptoms. This could be attributed to the presence of compounds like glutathione, which is known for its antioxidant properties and potential role in modulating immune responses. However, scientific evidence supporting this claim is sparse, and individual responses can vary significantly.

4. Musculoskeletal Pain Relief: Some users report improvements in conditions like muscle pain and inflammation after taking nucleic acid supplements. This could be due to the anti-inflammatory properties of certain components within the supplements. However, again, scientific validation is lacking, and these claims should be approached with caution.

Risks and Side Effects
While nucleic acid supplements are generally considered safe for most individuals, there are potential risks and side effects to consider:
1. Allergic Reactions: Individuals with allergies to fish or yeast may experience adverse reactions when consuming nucleic acid supplements derived from these sources. Symptoms can range from mild (itching, hives) to severe (anaphylaxis).

2. Gastrointestinal Issues: Some users may experience gastrointestinal discomfort, including nausea, diarrhea, or bloating, particularly if they consume these supplements in excess.

3. Drug Interactions: Nucleic acid supplements may interact with certain medications, particularly those that affect the immune system or those used in cancer treatment. It is crucial for individuals to consult healthcare providers before starting any new supplement, especially if they are on medication.

4. Lack of Regulation: Dietary supplements are not as strictly regulated as pharmaceuticals in many countries, including the United States. This means that the quality, purity, and concentration of nucleic acids in supplements can vary significantly between products. Consumers should choose reputable brands and consult healthcare professionals for guidance.

Conclusion
In summary, while nucleic acid supplements may offer some potential benefits, particularly in the realms of cellular repair and immune modulation, the scientific evidence supporting these claims is still limited. Anecdotal reports of improvements in allergic reactions and musculoskeletal pain should be interpreted with caution, as individual experiences can vary widely. As with any supplement, it is essential to approach nucleic acid supplements with a critical mindset, prioritize a balanced diet, and consult healthcare professionals before making any significant changes to one's health regimen.

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