Can Calcium Supplements Prevent Osteoporosis from Long-term Medication? - Orthopedics

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Osteoporosis and Calcium Supplementation Issues


Hello, doctor.
After undergoing an upper gastrointestinal endoscopy, I took the medication "Dexilant." The gastroenterologist mentioned that long-term use could lead to osteoporosis.
I have been taking it for about three months now, and the gastroenterologist said it would take over a year for this to occur, but I am still a bit concerned.
During this time, if I increase my intake of high-calcium foods or even take calcium supplements, can this help prevent osteoporosis? Thank you.

Niming, 30~39 year old female. Ask Date: 2022/08/08

Dr. Chen Yongxue reply Orthopedics


Hello, osteoporosis is not as simple as just supplementing calcium.
Long-term use of medications like gastric motility agents can not only contribute to osteoporosis but also harm the kidneys and cause low magnesium levels.
Therefore, if your gastric condition improves, please discontinue the medication.
Thank you.

Reply Date: 2022/08/08

More Info


Osteoporosis is a significant concern for individuals who are on long-term medication, particularly proton pump inhibitors (PPIs) like "Dexilant" (得喜胃通), which can affect calcium absorption and bone health. Your gastroenterologist's warning about the potential for osteoporosis after prolonged use of such medications is valid. While it may take over a year for the effects to manifest, being proactive about your bone health is essential.

Calcium supplements can indeed play a role in preventing osteoporosis, especially for those at risk due to medication or other factors. The recommended daily intake of calcium for adults varies by age and gender, but generally, it is around 1,000 mg for most adults and increases to 1,200 mg for women over 50 and men over 70. It's important to note that while calcium is crucial for bone health, it should ideally come from dietary sources first, such as dairy products (milk, yogurt, cheese), leafy green vegetables (kale, broccoli), and fortified foods (orange juice, cereals).

If dietary intake is insufficient, calcium supplements can be beneficial. However, it's essential to choose the right type of supplement. Calcium carbonate and calcium citrate are the two most common forms. Calcium carbonate is best taken with food for optimal absorption, while calcium citrate can be taken with or without food and is often recommended for those with lower stomach acid levels, which can be a concern for long-term PPI users.

In addition to calcium, vitamin D is crucial for calcium absorption and bone health. Many calcium supplements also include vitamin D, which can help enhance the effectiveness of the calcium you are taking. The recommended daily intake of vitamin D for adults is generally around 600 to 800 IU, but some individuals may require higher doses, especially if they have low blood levels of vitamin D.

It's also important to consider other lifestyle factors that contribute to bone health. Weight-bearing exercises, such as walking, jogging, or resistance training, can help strengthen bones and improve overall bone density. Avoiding smoking and limiting alcohol consumption are also vital, as both can negatively impact bone health.

While calcium and vitamin D supplementation can help mitigate the risk of osteoporosis, it is crucial to consult with your healthcare provider before starting any new supplements, especially considering your current medication regimen. They can provide personalized recommendations based on your health history, dietary habits, and any other medications you may be taking.

In summary, while calcium supplements can help prevent osteoporosis, they should be part of a comprehensive approach that includes a balanced diet rich in calcium and vitamin D, regular exercise, and lifestyle modifications. Monitoring your bone health through regular check-ups and possibly bone density tests can also help catch any issues early, allowing for timely intervention.

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