Managing Persistent Discomfort After High-Dose Glucose Prolotherapy for Lower Back Pain - Rehabilitation

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How can I alleviate the persistent aching sensation caused by high-concentration glucose sclerotherapy in the lower back?


Hello, doctor.
Following up on the article #165661 regarding "Prolotherapy for Lower Back Pain and Medication Consultation," I underwent high-concentration glucose prolotherapy for my lower back, receiving a total of 10 injections in one session.
Over the past two years, I have continuously experienced discomfort, whether standing, sitting, or lying down.
Recently, I couldn't tolerate it anymore, so I went to the pharmacy and bought ANTI FLAN (bromelain) 100mg, taking one every three hours for a total of five pills a day, which amounts to 500mg daily.
I have been taking it for five days, but the discomfort persists.
I'm uncertain if continuing the bromelain will alleviate the discomfort.
If, as the doctor mentioned, the efficacy of bromelain is not guaranteed, should I consider going to the hospital for an ultrasound examination and request a prescription for non-steroidal anti-inflammatory drugs (NSAIDs) to pursue more aggressive treatment?

Mr. Li, 20~29 year old female. Ask Date: 2021/02/24

Dr. Yin Xinbei reply Rehabilitation


The sensation of heaviness and discomfort is not a pain perception, especially since this feeling has persisted for two years.
Non-steroidal anti-inflammatory drugs (NSAIDs) may not necessarily be effective, but it might be worth trying them for a week or two to see if there is any improvement.
In the long term, it is still recommended to incorporate exercise therapy, such as core muscle training, along with physical therapy (like local deep heat therapy) for a period of time to gradually achieve improvement.

Reply Date: 2021/02/24

More Info


Managing persistent discomfort after high-dose glucose prolotherapy for lower back pain can be quite challenging, especially when the discomfort persists despite various interventions. It’s important to understand the underlying mechanisms of both the treatment you received and the symptoms you are experiencing.

Glucose prolotherapy is a regenerative treatment aimed at stimulating healing in damaged tissues, particularly in cases of chronic pain. The high concentration of glucose is thought to promote inflammation initially, which is a natural part of the healing process. However, this inflammation can sometimes lead to prolonged discomfort, as you have experienced.
The use of bromelain, a natural anti-inflammatory derived from pineapples, is a common approach to manage inflammation and pain. While bromelain can be effective for some individuals, its efficacy can vary widely. It is known to have anti-inflammatory properties and may help reduce swelling and pain, but it may not be sufficient for everyone, especially in cases of persistent discomfort following a procedure like prolotherapy.

Given that you have been taking bromelain for five days without significant relief, it may be prudent to consider further evaluation. An ultrasound or other imaging studies can provide valuable insights into the state of your lower back and help identify any underlying issues that may not have been addressed by the prolotherapy. This could include checking for any structural abnormalities, such as herniated discs or other sources of pain that may require different treatment approaches.

In addition to imaging, consulting with your physician about the possibility of non-steroidal anti-inflammatory drugs (NSAIDs) could be beneficial. NSAIDs, such as ibuprofen or naproxen, can provide more potent anti-inflammatory effects compared to bromelain and may help alleviate your discomfort more effectively. However, it’s essential to discuss this with your healthcare provider, as they can assess your overall health, any potential contraindications, and the best course of action tailored to your specific situation.

Moreover, if your discomfort is related to muscle tension or spasms, physical therapy might be an effective adjunct treatment. A physical therapist can provide targeted exercises and modalities to help alleviate pain and improve function. Techniques such as manual therapy, stretching, and strengthening exercises can be particularly beneficial for managing chronic lower back pain.

Lastly, consider lifestyle modifications that can support your recovery. Maintaining a healthy weight, engaging in regular low-impact exercise, and practicing good posture can all contribute to reducing lower back pain. Additionally, stress management techniques, such as mindfulness or yoga, can help alleviate muscle tension and improve your overall well-being.

In summary, while bromelain may provide some relief, it may not be sufficient for your persistent discomfort. A comprehensive approach that includes further diagnostic imaging, potential use of NSAIDs, physical therapy, and lifestyle modifications may be necessary to effectively manage your symptoms. Always consult with your healthcare provider before making any changes to your treatment plan to ensure safety and efficacy.

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